Long-term results of autologous submandibular gland transfer for the surgical treatment of severe keratoconjunctivitis sicca

Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
Hans-Christian JacobsenP Sieg

Abstract

The aim of this study was to assess the long-term results of autologous submandibular gland transfer for surgical correction of severe keratoconjunctivitis sicca. A survey was undertaken of 32 patients who had undergone submandibular gland transfer (42 glands) and by following up 11 patients (15 glands) for 5-10 years. Subjective benefit was evaluated as well as clinical findings at the ocular surface. The biochemical consistency of the secreted "saliva-tear" was analysed and compared with natural submandibular saliva of a matched control-group. The vitality and function of the transplants was tested by means of sialoscintigraphy. Immunohistochemical investigations were carried out in specimens of submandibular tissue, gained during reduction procedures of the transplants to correct secretory excess. Patient evaluation and clinical assessment revealed a long-lasting subjective benefit in 2/3 of the patients and a stabilisation at the ocular surface in all cases. The secretion remained as highly concentrated submandibular saliva. Glandular vitality and function was shown scintgraphically. Immunohistochemical investigations revealed no progressive atrophy after transplantation, the ability of cell division remained intact and the...Continue Reading

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Citations

Feb 7, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Hans-Christian JacobsenPeter Sieg
Jul 8, 2014·The Ocular Surface·Jia-Zeng SuGuang-Yan Yu
Apr 7, 2012·The Journal of Surgical Research·Ning-Yan YangGuang-Yan Yu
Feb 24, 2015·International Journal of Oral and Maxillofacial Surgery·X J LiuG Y Yu
Feb 11, 2015·Journal of Molecular Pharmaceutics & Organic Process Research·Jia-Zeng SuGuang-Yan Yu
May 7, 2016·The Ocular Surface·Jayesh VaziraniVirender S Sangwan
Jun 6, 2009·Journal of Dental Research·Y M LiG Y Yu
Nov 6, 2018·Journal of Cellular Physiology·Xue-Ming ZhangGuang-Yan Yu
Sep 9, 2017·International Ophthalmology Clinics·Natalie WolkowSuzanne K Freitag
Jul 15, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Andrew H Bartlett, Jimmy D Bartlett
Jul 19, 2017·Health and Quality of Life Outcomes·Bang ZhengGuang-Yan Yu
May 31, 2018·Investigative Ophthalmology & Visual Science·Yi QinAntoine Labbé

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