Long-term results of cardiac transplantation in patients older than sixty years. UTAH Cardiac Transplant Program

The Journal of Thoracic and Cardiovascular Surgery
D A BullC W Putnam

Abstract

Advanced age has traditionally been a contraindication to cardiac transplantation. We have, however, offered cardiac transplantation to patients older than 60 years with end-stage heart failure if they were otherwise acceptable candidates. From 1985 to 1994, 527 patients underwent cardiac transplantation. Among these patients, 101 were older than 60 years at transplantation. The mean follow-up of this group is 6 years. Patients older than 60 years had significantly fewer rejection episodes per patient than those who were younger than 60 years at transplantation (1.9 +/- 1.3 vs 2.6 +/- 1.8, p = 0.009). No difference in the number of infectious complications per patient was detected between the two groups. Both short-term and long-term survival after transplantation were significantly lower for patients who were older than 60 years at transplantation than for younger patients (p < 0.05). The 6-year actuarial survival after transplantation for patients older than 60 years was 54% compared with 72% for patients younger than 60 years at transplantation (p < 0.05). Patients older than 60 years at transplantation were more likely to die of infectious complications or malignant disease after transplantation (p < 0.05). We believe cauti...Continue Reading

References

Feb 1, 1988·The Annals of Thoracic Surgery·O H FrazierD A Cooley

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Citations

Dec 12, 2003·The Annals of Thoracic Surgery·Jeffrey A MorganNiloo M Edwards
Jan 22, 1998·The Annals of Thoracic Surgery·R HetzerH G Borst
Jul 25, 2003·The Journal of Thoracic and Cardiovascular Surgery·Philippe DemersRobert C Robbins
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