Long-term results of gastrectomy for alpha-fetoprotein-producing gastric cancer

The British Journal of Surgery
M InoueH Katai

Abstract

alpha-Fetoprotein (AFP)-producing gastric cancer is a rare tumour. It is said to have a high incidence of liver metastasis and poor prognosis. This study sought to evaluate long-term outcomes in such patients. Records of consecutive patients with gastric carcinoma who underwent preoperative measurement of serum AFP levels and gastrectomy were reviewed to identify those who satisfied the following criteria: preoperative AFP level exceeding 40 ng/ml with a decrease after gastrectomy, or raised preoperative AFP level (10-39 ng/ml) and resected tumour showing histologically characteristic features or immunohistochemically positive AFP production. Of 3374 patients with gastric cancer, 53 (1.6 per cent) met the selection criteria. Tumours were characterized by a high incidence of nodal (79 per cent) or liver (53 per cent) metastasis. Preoperative serum AFP levels showed no correlation with tumour size, depth of invasion, disease stage or survival. The 5-year survival rate was 34 per cent. Five patients survived after recurrence following multimodal treatment. A rising AFP level during follow-up always led to tumour recurrence, but the level remained normal in 11 of 31 patients with recurrence. AFP-producing tumours represent a small ...Continue Reading

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Citations

Apr 11, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hideaki ShimadaYutaka Takahashi
Feb 26, 2020·World Journal of Surgical Oncology·Kenji KawaharaMasayuki Otsuka
Apr 17, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yakun WangXiaotian Zhang
Jun 20, 2019·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Yeon-Ji KimHyung-Min Chin
Apr 8, 2020·World Journal of Clinical Cases·Zheng-Rong ZhangTao Wang
Jun 22, 2013·The International Journal of Biological Markers·Jing JiexianHan Cunzhi

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