PMID: 11316555Apr 24, 2001Paper

Long-term results of intraoperative electron beam radiotherapy for primary and recurrent retroperitoneal soft tissue sarcoma

International Journal of Radiation Oncology, Biology, Physics
H L GieschenC G Willett

Abstract

This study assesses the long-term outcome of patients with retroperitoneal sarcoma treated by preoperative external beam radiotherapy, resection, and intraoperative electron beam radiation (IOERT). From 1980 to 1996, 37 patients were treated with curative intent for primary or recurrent retroperitoneal soft tissue sarcoma. All patients underwent external beam radiotherapy with a median dose of 45 Gy. This was followed by laparotomy, resection, and IOERT, if feasible. Twenty patients received 10-20 Gy of IOERT with 9-15 MeV electrons. These patients were compared to a group of 17 patients receiving preoperative irradiation without IOERT. The 5-yr actuarial overall survival (OS), disease-free survival, local control (LC), and freedom from distant disease of all 37 patients was 50%, 38%, 59%, and 54%, respectively. After preoperative irradiation, 29 patients (78%) underwent gross total resection. For 16 patients undergoing gross total resection and IOERT, OS and LC were 74% and 83%, respectively. In contrast, these results were less satisfactory for 13 patients undergoing gross total resection without IOERT. For these patients, OS and LC were 30% and 61%, respectively. Four patients experienced treatment-related morbidity. In sele...Continue Reading

References

Jul 1, 1991·Annals of Surgery·F K Storm, D M Mahvi
May 1, 1981·Cancer·H S CodyS I Hajdu
Apr 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M P JenkinsJ M Thomas

❮ Previous
Next ❯

Citations

Oct 31, 2003·Current Treatment Options in Oncology·Brian O'SullivanMichael Sharpe
Oct 26, 2005·Current Treatment Options in Oncology·R Lor RandallKaren H Albritton
May 8, 2013·Current Treatment Options in Oncology·Pranshu MohindraKevin R Kozak
Jun 5, 2003·Current Oncology Reports·Brian O'SullivanCharles Catton
Aug 17, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Ángel Montero LuisJosé Antonio López Martín
Sep 3, 2013·Indian Journal of Surgical Oncology·Vijay KumarArun Chaturvedi
Dec 5, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ole Steen Nielsen, Brian O'Sullivan
Sep 24, 2002·International Journal of Radiation Oncology, Biology, Physics·Emad YoussefEdgar Ben-Josef
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Thomas F DeLaneyHerman D Suit
Sep 27, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J Y BobinJ P Gerard
Dec 7, 2010·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·C AvancèsUNKNOWN Oncology Committee of the French Association of Urology (CCAFU)
Nov 6, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C Le PéchouxS Bonvalot
Jul 20, 2002·Current Opinion in Oncology·Peter W T Pisters, Brian O'Sullivan
Jun 1, 2005·American Journal of Clinical Oncology·Robert A ZloteckiSteven N Hochwald
Jun 5, 2007·Current Opinion in Oncology·Timothy M PawlikJoseph M Herman
Sep 22, 2010·Radiation Oncology·Carmen Llacer-MoscardoPascal Fenoglietto
Jan 18, 2006·Annals of Surgical Oncology·Wirginiusz DziewirskiWłodzimierz Ruka
Mar 19, 2014·La Radiologia medica·Jeffrey TuanRoberto Orecchia
Oct 2, 2013·The Lancet Oncology·Brock J DebenhamLouis B Harrison
Apr 30, 2013·Surgical Oncology Clinics of North America·Leonard L GundersonChristopher Beauchamp
Mar 1, 2012·Surgical Oncology Clinics of North America·Carol J Swallow, Charles N Catton
Mar 1, 2012·Surgical Oncology Clinics of North America·Thomas F Delaney
Jul 5, 2011·Journal of the American College of Surgeons·Edmund Bartlett, Sam S Yoon
Dec 21, 2010·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Aviad HoffmanDina Lev
May 6, 2009·Current Problems in Surgery·J Spencer LilesMartin J Heslin
Jun 3, 2008·The Surgical Clinics of North America·Aradhana Kaushal, Deborah Citrin
Apr 9, 2008·International Journal of Radiation Oncology, Biology, Physics·Phuoc T TranDaniel S Kapp
Jun 15, 2007·International Journal of Radiation Oncology, Biology, Physics·Mary FengMichael E Ray
May 30, 2006·Hematology/oncology Clinics of North America·Elena Antoaneta Nedea, Thomas F DeLaney
Nov 4, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Th van Dalen Dutch Soft Tissue Sarcoma Group
Dec 9, 2014·Journal of Surgical Oncology·Marcus C B Tan, Sam S Yoon
Mar 19, 2016·Journal of Surgical Oncology·Hao ChengFabian M Johnston
Feb 11, 2015·Journal of Surgical Oncology·Rebecca Tuttle, John M Kane
Jan 1, 2014·Journal of Surgical Oncology·Edmund K BartlettGiorgos C Karakousis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
Ivy A PetersenLeonard L Gunderson
International Journal of Radiation Oncology, Biology, Physics
K M AlektiarL B Harrison
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Laurent GilbeauBinh Nguyen Bui
© 2021 Meta ULC. All rights reserved