Long-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection.

Clinical Ophthalmology
Victoria Wy WongTimothy Yy Lai

Abstract

The purpose of this study was to assess the efficacy of oral valganciclovir in the treatment of anterior segment inflammation caused by cytomegalovirus (CMV) infection. Consecutive patients with anterior segment inflammation due to CMV causing anterior uveitis or corneal endotheliitis treated with oral valganciclovir were reviewed. Diagnosis of CMV infection was confirmed by polymerase chain reaction of the aqueous aspirate prior to commencement of oral valganciclovir. All patients were treated with an oral loading dose of 900 mg valganciclovir twice daily for at least 2 weeks, followed by an additional 450 mg valganciclovir twice-daily maintenance therapy. Changes in visual acuity, intraocular pressure (IOP), use of antiglaucomatous eye drops, and recurrence were analyzed. Thirteen eyes of 11 patients were followed for a mean of 17.2 months. Two patients had bilateral corneal endotheliitis. All eyes had absence of anterior segment inflammation within 3 weeks after treatment. Following treatment, the mean logMAR visual acuity improved significantly from 0.58 at baseline to 0.37 at the last follow-up (P = 0.048). The mean IOP and number of antiglaucomatous eye drops also decreased significantly (P = 0.021 and P = 0.004, respecti...Continue Reading

References

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Citations

Aug 21, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M AccorintiF R Pesci
Jun 29, 2018·Ocular Immunology and Inflammation·Je-Hyung HwangSo-Hyang Chung
Oct 4, 2018·Current Opinion in Ophthalmology·Ashlin Joye, John A Gonzales
Sep 16, 2020·Ocular Immunology and Inflammation·Abdulaziz Ismail Al Somali, Wael Otaif

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