Long-term results of the first Italian Association of Pediatric Hematology and Oncology protocol for the treatment of pediatric B-cell non-Hodgkin lymphoma (AIEOP LNH92)

Cancer
Marta PillonAngelo Rosolen

Abstract

Childhood B-cell lymphomas (B-NHLs) represent a group of aggressive malignancies that are amenable to high-intensity chemotherapy regimens. In 1992, the Italian Association of Pediatric Hematology and Oncology (AIEOP) initiated a prospective clinical trial involving the diagnosis and treatment of childhood B-NHL based on a well established strategy developed by the Berlin-Frankfurt-Munster Group. Between November 1992 and October 1997, 163 children who had B-NHL were treated prospectively in the first national AIEOP trial. Disease staging was performed according to the St. Jude staging system, and treatment was assigned on the basis of risk group (R1, R2, or R3), which took into account disease stage and resectability and serum lactate dehydrogenase (LDH) levels. Of the 144 evaluable patients, 11 had Stage I disease, 35 had Stage II disease, 76 had Stage III disease, and 22 had Stage IV disease. Thirteen, 54, and 77 patients were included in risk groups R1, R2, and R3, respectively. The 10-year overall survival (OS) and event-free survival (EFS) rates for the overall population were 89.4% and 81.8%, respectively; the EFS rates for patients in risk groups R1, R2, and R3 were 100%, 86.9%, and 75.1%, respectively. Multivariate ana...Continue Reading

References

Jan 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A T MeadowsC J Stolar
Feb 6, 1988·Lancet·A G StansfeldO Mioduszewska
Feb 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A ReiterH Riehm
Jan 1, 1994·Medical and Pediatric Oncology·J L FinlayA T Meadows
Jun 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R AndersonA T Meadows
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I MagrathI D Horak

❮ Previous
Next ❯

Citations

May 15, 2013·Annals of Hematology·Andishe AttarbaschiUNKNOWN European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) and the international Berlin-Frankfurt-Münster (i-BFM) Study
Jul 3, 2013·Current Hematologic Malignancy Reports·Jonas Lange, Birgit Burkhardt
Aug 26, 2010·Journal of Pediatric Hematology/oncology·Tiraje Tülin CelkanInci Yildiz
Jun 10, 2008·British Journal of Haematology·Alfred Reiter, Wolfram Klapper
May 27, 2015·Pediatric Blood & Cancer·Maurizio AricòUNKNOWN NHL-Committee of the Italian Association of Pediatric Hematology Oncology
Mar 8, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nadejda Y MudieDavid C Linch
Oct 31, 2017·British Journal of Haematology·Lisa Giulino-RothJohn P Leonard
Feb 9, 2018·Indian Journal of Pediatrics·Amol PatelSameer Bakhshi
Feb 9, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Worawut ChoeyprasertSuradej Hongeng
Aug 16, 2005·British Journal of Haematology·Ross Pinkerton
Jun 24, 2021·Radiology Case Reports·Ciro Gabriele MainolfiAlberto Cuocolo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.