Long-term results of transanal excision after neoadjuvant chemoradiation for T2 and T3 adenocarcinomas of the rectum.

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Rajesh M NairDavid Shibata

Abstract

Traditionally, selected early distal rectal cancers have been considered for treatment by transanal excision (TAE) with acceptable oncologic results. With the frequent use of neoadjuvant chemoradiation (NCR) for the treatment of locally advanced rectal cancer, there is growing interest in the application of TAE for such lesions. We report our experience of TAE for T2 and T3 rectal cancers following NCR. Between July 1994 and August 2006, 44 patients were identified as having undergone full-thickness TAE of pretreatment ultrasound-staged T2 and T3 rectal cancers that were treated with NCR. Fifteen patients were deemed medically unfit for radical resection, and 29 would have required abdominoperineal resection but were opposed to colostomy. Our patient population consisted of 26 men and 18 women, with a median age of 69 (range, 43-89) and a median follow up of 64 months (6-153). Thirty-one patients had a clinical complete response (cCR) to NCR of which 19 (61%) had a pathologic CR (pCR). Seven (16%) of 44 patients sustained disease recurrence of which two were local only, two local and systemic, and three systemic only. Only four (9%) patients had died of disease at current follow up. Overall 5-year survival rates for T2/T3N0 and...Continue Reading

References

May 1, 1992·World Journal of Surgery·D A Rothenberger, W D Wong
Aug 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D MinskyJ Frankel
Aug 30, 1994·International Journal of Radiation Oncology, Biology, Physics·E T ChenG Marks
Jul 1, 1996·Surgical Endoscopy·E LezocheF Di Pietrantonj
Jul 1, 1996·Diseases of the Colon and Rectum·A M AverbachP H Sugarbaker
Dec 1, 1996·The British Journal of Surgery·H U ZierenJ M Müller
Sep 28, 1998·Diseases of the Colon and Rectum·A Habr-GamaJ Gama-Rodrigues
Aug 12, 1999·Archives of Surgery·M G VarmaM L Welton
Aug 24, 1999·Annals of Surgical Oncology·G D SteeleR J Mayer
Mar 14, 2000·Annals of Surgery·J Garcia-AguilarD A Rothenberger
Aug 19, 2000·Diseases of the Colon and Rectum·A MellgrenJ García-Aguilar
Nov 23, 2000·Diseases of the Colon and Rectum·S D Wexner, N A Rotholtz
Oct 5, 2001·Diseases of the Colon and Rectum·S Sengupta, J J Tjandra
Jan 5, 2002·Annals of Surgical Oncology·M W OnaitisD S Tyler
Feb 19, 2002·Journal of the American College of Surgeons·Spiros P HiotisW Douglas Wong
May 25, 2002·Journal of the American College of Surgeons·Scott R SchellEdward M Copeland
Oct 9, 2002·Annals of Surgery·Philip B PatyW Douglas Wong
Jan 30, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Isabelle BedrosianJohn M Skibber
Jan 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Felipe A CalvoJosé Luis Carreras
Sep 1, 2004·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·P PalmaS Post
Oct 22, 2004·The New England Journal of Medicine·Rolf SauerUNKNOWN German Rectal Cancer Study Group
Nov 3, 2004·International Journal of Radiation Oncology, Biology, Physics·Mark BonnenBarry W Feig
Mar 12, 2005·Digestive Surgery·Piero NastroJohn R T Monson
Mar 16, 2005·Diseases of the Colon and Rectum·Khaled M MadboulyIan C Lavery
May 21, 2005·Diseases of the Colon and Rectum·Birger H EndresethUNKNOWN Norwegian Rectal Cancer Group
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jose G GuillemW Douglas Wong
Dec 19, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Angelita Habr-GamaJoaquim Gama-Rodrigues

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Citations

Oct 30, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S-L HanJ-Y Yan
Dec 7, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E Rullier, V Vendrely
Apr 12, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·In Ja ParkGeorge J Chang
Apr 23, 2013·Annals of Surgical Oncology·Marco E Allaix, Alessandro Fichera
Sep 22, 2012·Clinical Medicine & Research·Nathan TennysonRobert A Zlotecki
Aug 29, 2013·World Journal of Gastroenterology : WJG·Jia-Yuan PengYu Wang
Sep 13, 2012·ISRN Gastroenterology·Wim P Ceelen
Aug 11, 2015·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Nidal IssaEldad Powsner
Jan 7, 2017·Diseases of the Colon and Rectum·Fraser McLean SmithRichard J Heald
Dec 12, 2012·Digestive Diseases·Daniel LéonardAlex Kartheuser
Dec 12, 2012·Digestive Diseases·Georgia Dedemadi, Steven D Wexner
Oct 25, 2017·European Journal of Gastroenterology & Hepatology·Yaniv FenigNidal Issa
Sep 17, 2010·The British Journal of Surgery·F M SmithD C Winter
Oct 7, 2014·Diseases of the Colon and Rectum·Francesco StipaCarlo Eugenio Vitelli
Jan 25, 2020·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Rajkumar Janavikula SankaranJayakumar Kj
Sep 8, 2016·Diseases of the Colon and Rectum·Sally HallamMichael G Thomas
Jan 11, 2013·Diseases of the Colon and Rectum·Marjun P DuldulaoJulio Garcia-Aguilar
Dec 17, 2009·Diseases of the Colon and Rectum·Ben M TsaiAnders Mellgren
Nov 10, 2013·Diseases of the Colon and Rectum·Salvatore PucciarelliClaudio Coco
Nov 16, 2016·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Jose M RamirezVicente Aguilella
Sep 14, 2016·Annual Review of Medicine·Geerard L BeetsRegina G H Beets-Tan
Nov 28, 2012·Journal of the Korean Society of Coloproctology·Nam Kyu KimSami F Al-Asari
May 12, 2020·Molecular & Cellular Oncology·Jason K DouglasHarry J Wasvary
Jul 8, 2016·Diseases of the Colon and Rectum·Andrew D NewtonE Carter Paulson
Jan 22, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C ShwaartzO Zmora
Jul 29, 2017·F1000Research·Fedor MoiseenkoVladimir Moiseyenko
Sep 13, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K C VallamA Saklani
Nov 9, 2012·Diseases of the Colon and Rectum·Scott R Steele
Apr 22, 2021·JCO Oncology Practice·Benjamin W DeschnerDavid Shibata
Feb 3, 2009·The Surgical Clinics of North America·Kenneth L MeredithDavid Shibata
Oct 7, 2011·Clinical Colorectal Cancer·Bruce D Minsky

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