PMID: 9428488Jan 15, 1998Paper

Long term results with breast-conserving therapy for patients with early stage breast carcinoma in a community hospital setting

Cancer
V R KiniF A Vicini

Abstract

Prospective randomized trials and retrospective reviews from academic centers have documented the success of breast-conserving therapy (BCT) for patients with early stage breast carcinoma. The authors retrospectively reviewed the outcome of BCT for early stage breast carcinoma to determine the success of BCT at the study institution, a 1000-bed community hospital. Between January 1980 and December 1987, 400 cases of Stage I and II breast carcinoma were managed with BCT at the study institution. All patients were treated with an excisional biopsy. The axilla was surgically staged in 383 patients (96%). Postoperative treatment was composed of 45-50 gray (Gy) external beam irradiation to the whole breast and a boost to the tumor bed to at least 60 Gy in all patients. The median follow-up of the 292 surviving patients is 118 months. At last follow-up, there were 37 local recurrences for 5- and 10-year actuarial rates of 4% and 10%, respectively. Clinical, pathologic, and treatment-related factors were analyzed for an association with local recurrence. On univariate analysis, patient age < or = 35 years and positive surgical margins were associated with an increased risk of local recurrence. On multivariate analysis, only patient ag...Continue Reading

References

Feb 1, 1979·International Journal of Radiation Oncology, Biology, Physics·J R HarrisS Hellman
Apr 23, 1992·The New England Journal of Medicine·A B NattingerJ S Goodwin
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·S M PierceJ R Harris
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·A de la RochefordièreJ R Harris
Jul 1, 1991·International Journal of Radiation Oncology, Biology, Physics·B L FowbleR L Goodman
Jul 1, 1991·International Journal of Radiation Oncology, Biology, Physics·T I LingosJ R Harris
Oct 1, 1989·International Journal of Radiation Oncology, Biology, Physics·A FourquetJ R Vilcoq
Apr 1, 1988·International Journal of Radiation Oncology, Biology, Physics·R H MatthewsM J Oswald
Aug 1, 1988·International Journal of Radiation Oncology, Biology, Physics·J M KurtzD Hans
Jul 1, 1985·International Journal of Radiation Oncology, Biology, Physics·A RechtJ R Harris
Sep 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·U VeronesiF Rilke
Sep 30, 1995·International Journal of Radiation Oncology, Biology, Physics·I GageJ R Harris
Oct 20, 1993·International Journal of Radiation Oncology, Biology, Physics·F ViciniA Martinez

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Citations

Sep 11, 2008·Langenbeck's Archives of Surgery·F FitzalR Jakesz
Sep 8, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nehmat HoussamiLawrence J Solin
Aug 10, 2005·Seminars in Thoracic and Cardiovascular Surgery·Ara KetchedjianHiran Fernando
Jan 6, 2009·The Breast Journal·Barbara D FlorentineJohn Barstis
Nov 5, 2011·The Breast Journal·Nicole KrekelSybren Meijer
Mar 22, 2005·Surgical Oncology·Amgad El-SherifHiran C Fernando
May 30, 2006·International Journal of Radiation Oncology, Biology, Physics·Derek B ChismPenny R Anderson
Jun 28, 2005·Surgical Oncology Clinics of North America·David P WinchesterMarvin J Lopez
Jan 29, 2005·The Journal of Thoracic and Cardiovascular Surgery·Hiran C FernandoRodney J Landreneau
Jun 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frank A Vicini, Abram Recht
Aug 19, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Majid M Mohiuddin, William F Regine
Apr 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F A ViciniA Martinez
May 24, 2012·Breast Care·Cordula Petersen, Florian Würschmidt
Jun 3, 2006·Journal of Cancer Research and Clinical Oncology·Jiang FanZhi-Ming Shao
May 17, 2012·Breast Cancer Research and Treatment·Thomas M SchroederMelanie Royce

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