Long-term retention rates for antiepileptic drugs: A review of long-term extension studies and comparison with brivaracetam

Epilepsy Research
Manuel ToledoSimon Borghs

Abstract

Antiepileptic drug (AED) retention rates are frequently reported in the literature and used to inform clinical decision-making, but methodological differences in the determination of retention rates make comparisons between trials difficult. Open-label extension (OLE) studies of AEDs in patients with focal epilepsy were identified from the literature. Retention calculation methods were reviewed, and published AED retention rates qualitatively compared with corresponding data for brivaracetam (BRV), a synaptic vesicle protein 2A ligand. The search identified 40 publications (corresponding to 17 studies of nine AEDs: eslicarbazepine, gabapentin, lacosamide, levetiracetam, oxcarbazepine, perampanel, pregabalin, topiramate and zonisamide) meeting eligibility criteria for inclusion in the review. Three methodologies to estimate retention rate were identified, which differed in whether patients randomised to placebo in the preceding randomised controlled trials (RCTs) were included or analysed separately, and whether retention was measured from the start of the OLE or of active treatment exposure. The most robust, conservative approach included all patients and measured retention from start of active treatment exposure, whether durin...Continue Reading

Citations

Mar 26, 2019·Expert Opinion on Pharmacotherapy·Arne Reimers, Hanna Ljung
Dec 7, 2019·Advances in Therapy·Saku VäätäinenReetta Kälviäinen
Aug 18, 2018·Seizure : the Journal of the British Epilepsy Association·Manuel ToledoEstevo Santamarina

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