Long-Term Risk of Heart Failure in Breast Cancer Patients After Adjuvant Chemotherapy With or Without Trastuzumab

JACC. Heart Failure
Ann BankeJacob E Møller

Abstract

This study sought to evaluate the long-term risk of developing heart failure (HF) in patients receiving trastuzumab therapy. Trastuzumab has improved the prognosis in patients with HER2-positive breast cancer, but it can induce left ventricular dysfunction with reduced ejection fraction or HF during treatment. The long-term risk of HF is less well described. In a nationwide Danish retrospective cohort study, 9,901 patients scheduled for adjuvant treatment for early-stage breast cancer were identified in the Danish Breast Cancer Cooperative Group database. Of these, 8,812 patients (25% HER2-positive; 51.7 ± 8.5 years of age) received chemotherapy including anthracycline; and if they were HER2 positive, trastuzumab was added. The primary endpoint was a diagnosis of HF assessed before and after 18 months in a landmark analysis to distinguish short- and long-term risks. Median follow-up was 5.4 years (interquartile range [IQR]: 4.1 to 6.8 years). In the trastuzumab group, 60 patients had HF by 9 years versus 51 in the group who were treated with chemotherapy alone, corresponding to incidence rates per 1,000 patient years of 5.3 (95% confidence interval [CI]: 4.1 to 6.8) versus 1.4 (95% CI: 1.1 to 1.8), respectively. The cumulative ...Continue Reading

Citations

Dec 11, 2019·Current Treatment Options in Cardiovascular Medicine·Avinash V SharmaAna Barac
May 11, 2019·Current Treatment Options in Oncology·Katherine Lee Chuy, Anthony F Yu
May 7, 2020·Journal of Internal Medicine·C ShiR A de Boer
Aug 28, 2020·Molecular and Cellular Biochemistry·Muhammad Afzal
Jan 23, 2021·Breast Cancer Research and Treatment·Lua Jafari, Nausheen Akhter
May 4, 2020·The Breast : Official Journal of the European Society of Mastology·Nathalie I BouwerMark-David Levin
Mar 26, 2021·Cancer Causes & Control : CCC·Jacqueline B VoKaren Meneses
May 1, 2021·Journal of Clinical Medicine·Michał BohdanEwa Lewicka
Aug 29, 2021·Current Oncology Reports·Susan F DentHeather Moore
Dec 19, 2021·International Journal of Clinical Oncology·Manabu Futamura, Kazuhiro Yoshida

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