Long-term risk of re-treatment of patients using alpha-blockers for lower urinary tract symptoms

The Journal of Urology
Jean J M C H de la RosetteLambertus A L M Kiemeney

Abstract

The efficacy of alpha-adrenoceptor blockers for the treatment of lower urinary tract symptoms has been proven in numerous studies. However, little is known about the efficacy of the longer term. We investigated the long-term risk of re-treatment in patients using alpha-adrenoceptor blockers for lower urinary tract symptoms and the parameters that influence this risk. We reviewed the files of 316 patients with lower urinary tract symptoms treated at our department with the alpha-blockers terazosin, alfuzosin or tamsulosin. Using followup data up to 3 years, we calculated re-treatment percentages in each treatment group. Using extended followup of 5 years, we calculated the predictive value of various baseline characteristics for re-treatment. The re-treatment rates were 27% for tamsulosin, 37% for alfuzosin and 49% for terazosin. The re-treatment rates of patients with mild, moderate and severe lower urinary tract symptoms were 27%, 33% and 70%, respectively. Patients with a maximum urine flow of less or more than 10 ml. per second had a re-treatment rate of 58% and 47%, respectively. Patients with a prostate volume of less or more than 40 ml. had a re-treatment rate of 48% and 72%, respectively. Patients who were urodynamically...Continue Reading

References

Mar 1, 1994·Journal of Clinical Epidemiology·L A KiemeneyJ C van Houwelingen
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Citations

Oct 16, 2012·Current Urology Reports·John Roger Bell, Eric Laborde
Mar 26, 2004·European Urology·Michael MarbergerJean de la Rosette
Feb 7, 2006·The Journal of Urology·Arthur L Burnett, Alan J Wein
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Sep 25, 2008·Journal of Endourology·Gerasimos Alivizatos, Andreas Skolarikos

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