Long-term risk of recurrence and regrowth after gross-total and subtotal resection of sporadic vestibular schwannoma

Journal of Neurosurgery
Hirofumi NakatomiMichael J Link

Abstract

OBJECTIVE The management of vestibular schwannoma (VS) remains controversial. One commonly cited advantage of microsurgery over other treatment modalities is that tumor removal provides the greatest chance of long-term cure. However, there are very few publications with long-term follow-up to support this assertion. The purpose of the current study is to report the very long-term risk of recurrence among a large historical cohort of patients who underwent microsurgical resection. METHODS The authors retrospectively reviewed the medical records of patients who had undergone primary microsurgical resection of unilateral VS via a retrosigmoid approach performed by a single neurosurgeon-neurotologist team between January 1980 and December 1999. Complete tumor removal was designated gross-total resection (GTR), and anything less than complete removal was designated subtotal resection (STR). The primary end point was radiological recurrence-free survival. Time-to-event analyses were performed to identify factors associated with recurrence. RESULTS Four hundred fourteen patients met the study inclusion criteria and were analyzed. Overall, 67 patients experienced recurrence at a median of 6.9 years following resection (IQR 3.9-12.1, ra...Continue Reading

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Citations

Mar 11, 2020·Acta neurochirurgica·Johannes WachErdem Güresir
Nov 2, 2017·Expert Review of Neurotherapeutics·Jane HallidayDafydd G Evans
Apr 28, 2020·Laryngoscope Investigative Otolaryngology·Mehdi AbouzariHamid R Djalilian
Jun 16, 2017·Acta neurochirurgica·Morten Lund-Johansen
Jun 30, 2019·Acta neurochirurgica·Ryouken KimuraMitsutoshi Nakada
Apr 5, 2020·Cancers·Longping YaoKoos Hovinga
Oct 4, 2021·Advanced Materials·Yue ZhangChao Wang

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