Long-Term Risk of Skin Cancer Among Childhood Cancer Survivors: A DCOG-LATER Cohort Study

Journal of the National Cancer Institute
Jop C TeepenDCOG-LATER Study Group

Abstract

Skin cancer is common after radiotherapy among childhood cancer survivors (CCSs). We studied risks and risk factors for subsequent skin cancers, with emphasis on radiation dose, exposed skin surface area, and chemotherapeutic agents. The DCOG-LATER cohort study includes 5-year Dutch CCSs diagnosed 1963-2001. Subsequent skin cancers were identified from record linkages with the Netherlands Cancer Registry and Dutch Pathology Registry. Incidence rates were compared with general population rates. Multivariable Cox regression models were used, applying a novel method of case-control sampling enabling use of tumor location in cohort analyses. All statistical tests were two-sided. Among 5843 CCSs, 259 developed 1061 basal cell carcinomas (BCCs) (standardized incidence ratio [SIR] = 29.8, 95% confidence interval [CI] = 26.3 to 33.6; excess absolute risk per 10 000 person-years (EAR) = 24.6), 20 had melanoma (SIR = 2.3, 95% CI = 1.4 to 3.5; EAR = 1.1), and 10 had squamous cell carcinoma (SIR = 7.5, 95% CI = 3.6 to 13.8; EAR = 0.8). Cumulative incidence of BCC 40 years after childhood cancer was 19.1% (95% CI = 16.6 to 21.8%) after radiotherapy vs 0.6% expected based on general population rates. After a first BCC, 46.7% had more BCCs la...Continue Reading

References

Mar 15, 2002·Radiation Research·Roy E ShoreBernard S Pasternack
Jun 22, 2002·Journal of the American Academy of Dermatology·Daniel Berg, Clark C Otley
Oct 15, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S GuérinF de Vathaire
Feb 25, 2005·International Journal of Cancer. Journal International Du Cancer·Davide BrunettiGiorgio Stanta
Jun 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joanna L PerkinsAnn C Mertens
Dec 5, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M C Cardous-UbbinkF E van Leeuwen
Jun 9, 2007·International Journal of Cancer. Journal International Du Cancer·Peter D Inskip, Rochelle E Curtis
Mar 10, 2009·Radiation Research·Jeffrey L SchwartzH Joachim Deeg
May 28, 2009·Journal of the National Cancer Institute·Jørgen H OlsenStanislaw Garwicz
Jul 17, 2010·Journal of the National Cancer Institute·Debra L FriedmanJoseph P Neglia
Apr 27, 2011·International Journal of Cancer. Journal International Du Cancer·Milena MaulePaolo Boffetta
Jun 7, 2011·JAMA : the Journal of the American Medical Association·Raoul C ReulenUNKNOWN British Childhood Cancer Survivor Study Steering Group
Sep 13, 2011·Progress in Biophysics and Molecular Biology·Adèle C GreenPenelope McBride
Jan 4, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·S C FlohilT Nijsten
May 16, 2012·Journal of Applied Clinical Medical Physics·Stephen F KryMarilyn Stovall
Jul 28, 2012·Journal of the National Cancer Institute·Tanya C WattAnn C Mertens
Aug 13, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Laurien A DaniëlsCarien L Creutzberg
Apr 24, 2014·Radiation Research·Hiromi SugiyamaKotaro Ozasa
Sep 6, 2014·Journal of the American Academy of Dermatology·Loes M HollesteinTamar E C Nijsten
Apr 23, 2015·JAMA Dermatology·Jennifer L DePryJeremy S Bordeaux
May 23, 2015·International Journal of STD & AIDS·Honglei ZhaoSongting Wang
May 23, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jop C TeepenUNKNOWN DCOG LATER Study Group
Jul 10, 2018·Journal of the National Cancer Institute·Jop C TeepenUNKNOWN DCOG-LATER Study Group

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Citations

Feb 26, 2019·Journal of the National Cancer Institute·Alan C Geller, Karen M Emmons
Nov 3, 2020·Pediatric Clinics of North America·Michael HawkinsLindsay M Morton

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