Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats

Frontiers in Aging Neuroscience
Lin ChenYong Tang

Abstract

Running exercise, one of the strategies to protect brain function, has positive effects on neurons and synapses in the cortex and hippocampus. However, white matter, as an important structure of the brain, is often overlooked, and the effects of long-term running exercise on white matter are unknown. Here, 14-month-old male Sprague-Dawley (SD) rats were divided into a middle-aged control group (18-month-old control group), an old control group (28-month-old control group), and a long-term runner group (28-month-old runner group). The rats in the runner group underwent a 14-month running exercise regime. Spatial learning ability was tested using the Morris water maze, and white matter volume, myelinated fiber parameters, total mature oligodendrocyte number, and white matter capillary parameters were investigated using stereological methods. The levels of growth factors related to nerve growth and vascular growth in peripheral blood and the level of neurite outgrowth inhibitor-A (Nogo-A) in white matter were measured using an enzyme-linked immunosorbent assay (ELISA). The present results indicated that long-term running exercise effectively delayed the age-related decline in spatial learning ability and the atrophy of white matte...Continue Reading

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Citations

Jun 9, 2021·Hippocampus·Sarah L AghjayanKirk I Erickson

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Methods Mentioned

BETA
transgenic
enzyme-linked immunosorbent assay
ELISA
light microscopy
protein assay

Software Mentioned

Visiopharm Image Analysis & Stereology System

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