Long-term safety and efficacy of continuous acitretin monotherapy for three children with different severe hyperkeratotic disorders in China

The Journal of Dermatology
Jingyao LiangXi-Bao Zhang

Abstract

Long-term systemic treatment with acitretin for severe hyperkeratotic disorders is needed to maintain quality of life of afflicted patients, but treatment has been limited owing to its potential side-effects including skeletal malformations, particularly for children during their growth and development. A retrospective investigation was conducted with three children afflicted with a severe hyperkeratotic disorder, namely Darier's disease, bullous ichthyosiform erythroderma or lamellar ichthyosis, who were continuously maintained on 0.2-0.3 mg/kg per day acitretin for more than 12 years after an initial period at a larger acitretin dose to bring each disease under control. The patients had good responses to acitretin treatment, which was assessed for safety, skeletal abnormalities, growth retardation and other potential side-effects. Acitretin monotherapy was an effective treatment for these children, and maintenance doses were well tolerated with no skeletal or other observable side-effects during the course of the study.

References

Apr 1, 1992·Drugs·T Pilkington, R N Brogden
Oct 1, 1992·The British Journal of Dermatology·D G PaigeJ I Harper
Jul 1, 1988·Journal of the American Academy of Dermatology·R F Kilcoyne
Jul 14, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·B SengörR Apaydin
May 24, 2007·The Journal of Dermatological Treatment·Xibao ZhangChangxing Li
Jan 8, 2008·Acta Dermato-venereologica·Anders VahlquistMarie Virtanen
Jul 9, 2008·The Journal of Dermatological Treatment·Xi-Bao ZhangXiao Xu
Apr 29, 2010·The British Journal of Dermatology·A D OrmerodUNKNOWN BAD Clinical Standards Unit
Mar 17, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·C PaulJ-P Ortonne
Mar 17, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·E SbidianH Bachelez
Apr 6, 2013·Dermatologic Clinics·Ann L Marqueling, Kelly M Cordoro
Jun 4, 2014·Pediatric Dermatology·Claudia J Posso-De Los RiosIrene Lara-Corrales
Aug 28, 2015·Anais Brasileiros De Dermatologia·Paula Mota MedeirosRoberto Souto da Silva
Apr 1, 1992·Drugs·Tania Pilkington, Rex N Brogden

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Citations

Nov 20, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·I LuchsingerM Theiler
Nov 11, 2020·Pediatric Dermatology·Andrea L ZaengleinUNKNOWN PeDRA Use of Retinoids in Ichthyosis Work Group
Apr 20, 2021·Pediatric Dermatology·Itohan OmorodionRodrigo Valdes-Rodriguez
Nov 30, 2021·Journal of Cutaneous Medicine and Surgery·N HannaC Lynde

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