Long-Term Safety and Efficacy of Single or Repeated Intra-Articular Injection of Allogeneic Neonatal Mesenchymal Stromal Cells for Managing Pain and Lameness in Moderate to Severe Canine Osteoarthritis Without Anti-inflammatory Pharmacological Support: Pilot Clinical Study

Frontiers in Veterinary Science
Quentin CabonEric Viguier

Abstract

Objective: To explore the long-term safety and efficacy of canine allogeneic mesenchymal stromal cells (MSC) administered intra-articularly as single or repeated injections in appendicular joints of dogs affected by moderate to severe refractory osteoarthritis. Study Design: 22 pet dogs were recruited into a non-randomized, open and monocentric study initially administering one cellular injection. A second injection was offered after 6 months to owners if the first injection did not produce expected results. Materials and Methods: Anti-inflammatory treatment (if prescribed) was discontinued at last one week before the onset of treatment. Each injection consisted of at least 10 million viable neonatal allogeneic mesenchymal stromal cells obtained from fetal adnexa. Medical data was collected from veterinary clinical evaluations of joints up to 6 months post-injection and owner's assessment of their dog's mobility and well-being followed for a further 2 years when possible. Results: Mild, immediate self-limiting inflammatory joint reactions were observed in 5/22 joints after the first injection, and in almost all dogs having a subsequent injection. No other MSC-related adverse medical events were reported, neither during the 6 mo...Continue Reading

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Citations

May 16, 2020·Journal of the American Veterinary Medical Association
Jun 4, 2020·Immunotherapy·Tunç Akkoç, Deniz Genç
Jul 14, 2020·Frontiers in Veterinary Science·Metka VogaGregor Majdic
Nov 5, 2020·The Journal of Small Animal Practice·J C Almansa RuizG Steenkamp
Jan 29, 2021·Veterinary Sciences·Alexandra JifcoviciAnita Sanghani-Kerai
Nov 12, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shuyi Xiao, Liang Chen

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Methods Mentioned

BETA
Cesarean-sections
biopsies
dissection
flow cytometry
ELISA
FACS

Software Mentioned

GraphPad Prism
GraphPad

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