Long-term safety and efficacy of tobramycin in the management of cystic fibrosis

Therapeutics and Clinical Risk Management
Emma Vázquez-EspinosaJulio Ancochea

Abstract

Cystic fibrosis (CF) is a fatal inherited disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene whose mortality is conditioned by a progressive decline in lung function. Bacterial infections play a key role in this decline. Chronic bacterial infection in CF patients varies over time and the presence of Pseudomonas aeruginosa in sputum is a marker of poor prognosis. P. aeruginosa is eradicated from the airways using inhaled antibiotics administered in various formulations and devices. Antipseudomonal antibiotics have extended the survival of CF patients to 40 years. Tobramycin is a bactericidal aminoglycoside antibiotic with demonstrated activity against gram-negative microorganisms. Initially, the drug was administered as an inhaled parenteral solution. Subsequently, a specific tobramycin inhalation solution was developed. PulmoSphere™ technology enables dry tobramycin powder to be formulated for inhalation (tobramycin inhalation powder) using a small and portable capsule-based breath-activated device (T-326). Chronic colonization by P. aeruginosa is the main indication for aerosol antibiotic therapy. The American Cystic Fibrosis Foundation, European guidelines, and Spanish consensus guidelines p...Continue Reading

Citations

Nov 13, 2015·Expert Review of Anti-infective Therapy·E Vazquez-EspinosaJ Ancochea
Apr 12, 2016·Frontiers in Cellular Neuroscience·Matthew KrugerAllison B Coffin
Jun 24, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Susanna EspositoNicola Principi
Oct 8, 2016·Critical Care : the Official Journal of the Critical Care Forum·Jayesh DhananiJason A Roberts
Oct 13, 2018·Scientific Reports·Sonia M Rocha-SanchezMarisa Zallocchi
Mar 13, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Alya A HeiraliMichael D Parkins

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Methods Mentioned

BETA
bronchoalveolar lavage

Software Mentioned

EAGER
EVOLVE

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