Long-term safety and efficacy study of a medical device containing xyloglucan, pea protein reticulated with tannins and xylo-oligosaccharides, in patients with diarrhoea-predominant irritable bowel syndrome.

Therapeutic Advances in Gastroenterology
Constanza Ciriza de Los RiosEnrique Rey

Abstract

Irritable bowel syndrome with diarrhoea (IBS-D) is a frequent problem associated with a significant socioeconomic implication. Increased gut permeability is an important pathophysiological mechanism. A medical device containing xyloglucan (XG), pea protein and tannins (PPT) from grape-seed extract, and xylo-oligosaccharides (XOS) has proven restoration of intestinal barrier function. Our objective was to evaluate the efficacy and safety of treatment with the medical device XG + PPT + XOS (XG-PPT-XOS) in adult patients with IBS-D in a clinical setting for 6 months. This was a multicentre, open-label, prospective, observational study conducted to evaluate long-term safety and efficacy of XG-PPT-XOS. IBS-D adult patients (Rome IV criteria) were included and received two tablets twice daily for 6 months. IBS Symptom Severity Score (IBS-SSS) and bowel habit were registered at baseline and monthly, until the end of follow up. Efficacy was evaluated by comparison of mean scores at each time point. 50 patients were included, of which 19 completed the 6 months. IBS-SSS score decreased from 312.2 ± 82.2 to 213.6 ± 109.9 (p < 0.0001) at 1 month and 192.0 ± 108.9 at the last visit completed; diarrhoea score decreased from 45.6 ± 17.9 to 25...Continue Reading

References

Apr 22, 2005·The American Journal of Gastroenterology·Magda GuileraFermín Mearin
Apr 2, 2009·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·J Esteban CarreteroJ López Montes
Aug 12, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·E Rey, N J Talley
Jan 6, 2012·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Cristina AlmansaEnrique Rey
May 24, 2016·Gastroenterology Research and Practice·Cătălin Pleșea CondratoviciNúria Piqué
Nov 17, 2016·Nature Reviews. Gastroenterology & Hepatology·Matthew A Odenwald, Jerrold R Turner
Jun 29, 2017·The New England Journal of Medicine·Alexander C FordNicholas J Talley
Sep 28, 2017·Expert Review of Gastroenterology & Hepatology·Helene EutameneVassilia Theodorou
Mar 3, 2018·International Journal of Molecular Sciences·Núria PiquéMaría Pilar Montero
Jun 23, 2018·Nature Reviews. Gastroenterology & Hepatology·Magnus Simrén, Jan Tack
Jul 20, 2018·Cellular and Molecular Gastroenterology and Hepatology·Clair R MartinEmeran A Mayer

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Software Mentioned

XOS
XG
SPSS
PPT

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