Long-term Safety of Oral Systemic Therapies for Psoriasis: A Comprehensive Review of the Literature.

Dermatology and Therapy
Deepak M W BalakLaura Salgado-Boquete

Abstract

Oral systemic therapies are important treatment options for patients with moderate-to-severe psoriasis, either as monotherapy or in therapy-recalcitrant cases as combination therapy with phototherapy, other oral systemics or biologics. Long-term treatment is needed to maintain sufficient disease control in psoriasis, but continuous use of systemic treatments is limited by adverse events (AEs) and cumulative toxicity risks. The primary aim of this comprehensive literature review was to examine the long-term safety profiles of oral agents commonly used in the treatment of adults with psoriasis. Searches were conducted in EMBASE and PubMed up to November 2018, and 157 relevant publications were included. Long-term treatment with acitretin could be associated with skeletal toxicity and hepatotoxicity, although evidence for skeletal toxicity is mixed and hepatotoxicity is rare, particularly at low doses. Other safety issues include hyperlipidaemia and potential for teratogenicity up to 2-3 years after discontinuation of treatment. There is a paucity of data on long-term treatment with apremilast. Continued exposure to apremilast does not seem to increase the incidence of common AEs, such as gastrointestinal (GI) AEs, upper respirato...Continue Reading

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Citations

Dec 5, 2020·Psoriasis : Targets and Therapy·Emmanuel Mahé
Apr 7, 2021·Clinical Case Reports·Martina Kralj, Hrvoje Jakovac
Apr 13, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·G R NirmalJia-You Fang
May 21, 2021·International Journal of Dermatology·Tugba Ozkok AkbulutIlknur Kıvanc Altunay
Feb 2, 2022·Dermatology and Therapy·Maria EspositoMaria Concetta Fargnoli

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Methods Mentioned

BETA
contraception
biopsies
urine collection

Software Mentioned

EMBASE

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