Long-term safety of pegvisomant in patients with acromegaly: comprehensive review of 1288 subjects in ACROSTUDY

The Journal of Clinical Endocrinology and Metabolism
Aart Jan van der LelyMaria Koltowska-Häggström

Abstract

Pegvisomant is a GH receptor antagonist. The ACROSTUDY is a global safety surveillance study of long-term treatment of acromegaly with pegvisomant. The objective of the study was to monitor long-term safety and treatment outcomes. ACROSTUDY is open to all patients with acromegaly who are treated with pegvisomant. We report an interim analysis of data captured from 1288 subjects enrolled before a database freeze of December 31, 2009. This was a global noninterventional surveillance study. Long-term monitoring of safety, including central magnetic resonance imaging (MRI) reading and treatment outcomes, was measured. Subjects (n = 1288) were treated with pegvisomant for a mean of 3.7 yr and followed up in ACROSTUDY for a mean of 2.1 yr. A total of 1147 adverse events (AE) were recorded in 477 subjects (37%), among which 192 AE in 124 subjects (9.6%) were considered to be related to pegvisomant. Serious AE were recorded in 159 subjects (12.3%), whereas pegvisomant-related Serious AE were recorded in 26 subjects (2%). No deaths (15 subjects; 1.2%) were attributed to pegvisomant use. The incidence of increase in pituitary tumor size in the subset with confirmed MRI increases on central reading represented 3.2% of the overall cohort w...Continue Reading

Citations

Apr 18, 2013·Nature Reviews. Endocrinology·Riia K JunnilaJohn J Kopchick
May 18, 2013·Clinical Medicine : Journal of the Royal College of Physicians of London·Amir H Sam, Karim Meeran
Feb 26, 2014·Nature Reviews. Endocrinology·Andrea GiustinaUNKNOWN Acromegaly Consensus Group
Aug 21, 2013·Indian Journal of Endocrinology and Metabolism·Gaya Thanabalasingham, Ashley B Grossman
Nov 26, 2013·Pituitary·Lucio VilarMarcello D Bronstein
May 14, 2014·Nature Reviews. Endocrinology·Antonio Di IevaKalman Kovacs
May 9, 2013·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Juif JenJuliana H Hey-Hadavi
Sep 24, 2014·Journal of Endocrinological Investigation·A GiustinaR Pivonello
Jan 26, 2016·Expert Opinion on Pharmacotherapy·Luiz Eduardo Wildemberg, Mônica R Gadelha
Apr 23, 2013·Expert Opinion on Pharmacotherapy·Raquel S Jallad, Marcello D Bronstein
Jun 5, 2013·Expert Opinion on Investigational Drugs·Ludovica F S GrassoAnnamaria Colao
Jan 10, 2014·Expert Opinion on Emerging Drugs·Sylvère Störmann, Jochen Schopohl
Mar 16, 2016·Case Reports in Endocrinology·Maria Susana Mallea-GilCarolina Ballarino
Oct 6, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Michael H Shanik
Dec 3, 2014·Neurologia Medico-chirurgica·Yutaka Oki
May 11, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Fernando CordidoUNKNOWN grupo de Neuroendocrinología de la Sociedad Española de Endocrinología y Nutrición
Dec 29, 2012·Trends in Endocrinology and Metabolism : TEM·Mônica R GadelhaMárta Korbonits
Oct 30, 2012·Medicina clínica·Juan J Díez, Pedro Iglesias
Jun 12, 2012·Annales d'endocrinologie·Patrick PetrossiansAlbert Beckers
Nov 28, 2015·Nature Reviews. Endocrinology·Shlomo Melmed
Jul 3, 2015·EBioMedicine·Ferdinand Roelfsema
Dec 15, 2015·Endocrine·S E FranckS J C M M Neggers
Nov 26, 2015·Annales d'endocrinologie·Philippe ChansonUNKNOWN Médecins de l'Étude ACROSTUDY
Aug 6, 2015·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Ignacio Bernabeu, Mónica Marazuela
Apr 27, 2013·Clinical Endocrinology·Jubbin J Jacob, John S Bevan
Oct 3, 2015·European Journal of Endocrinology·Emmanuelle KuhnPhilippe Chanson
Apr 29, 2015·Journal of Endocrinological Investigation·S CannavoUNKNOWN “Italian Acrostudy Group”
Apr 24, 2015·Aging Cell·Valter D LongoLuigi Fontana
Dec 30, 2014·Endocrine·A J van der LelyMaria Kołtowska-Häggström
Sep 24, 2013·Orvosi hetilap·Miklós Góth
May 27, 2014·Pituitary·E Fernandez-RodriguezI Bernabeu
Aug 19, 2014·Endocrine·Katja Kiseljak-VassiliadesMargaret E Wierman
Feb 11, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Kevin C J Yuen, Laurence Katznelson
Nov 6, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Pamela U FredaA J van der Lely
Jan 4, 2015·Annales d'endocrinologie·Thomas CunyFederico Gatto
Aug 26, 2014·Endocrine·S GrottoliL De Marinis

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