Long-term Safety of Pregnancy Following Breast Cancer According to Estrogen Receptor Status.

Journal of the National Cancer Institute
Matteo LambertiniHatem A Azim

Abstract

Safety of pregnancy in women with history of estrogen receptor (ER)-positive breast cancer remains controversial. In this multicenter case-control study, 333 patients with pregnancy after breast cancer were matched (1:3) to 874 nonpregnant patients of similar characteristics, adjusting for guaranteed time bias. Survival estimates were calculated using the Kaplan-Meier analysis; groups were compared with the log-rank test. All reported P values were two-sided. At a median follow-up of 7.2 years after pregnancy, no difference in disease-free survival was observed between pregnant and nonpregnant patients with ER-positive (hazard ratio [HR] = 0.94, 95% confidence interval [CI] = 0.70 to 1.26, P = .68) or ER-negative (HR = 0.75, 95% CI = 0.53 to 1.06, P = .10) disease. No overall survival (OS) difference was observed in ER-positive patients (HR = 0.84, 95% CI = 0.60 to 1.18, P = .32); ER-negative patients in the pregnant cohort had better OS (HR = 0.57, 95% CI = 0.36 to 0.90, P = .01). Abortion, time to pregnancy, breastfeeding, and type of adjuvant therapy had no impact on patients' outcomes. This study provides reassuring evidence on the long-term safety of pregnancy in breast cancer survivors, including those with ER-positive di...Continue Reading

References

Dec 13, 2006·BMJ : British Medical Journal·Angela IvesJames Semmens
Jun 5, 2010·The Breast Journal·Julie A KranickRuby T Senie
Nov 22, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hatem A AzimFedro A Peccatori
Feb 11, 2015·The Breast : Official Journal of the European Society of Mastology·Olivia PaganiAnn H Partridge
May 20, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nicoletta BigliaFedro Alessandro Peccatori
Jun 14, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Oranite GoldratHatem A Azim

❮ Previous
Next ❯

Citations

Dec 22, 2017·International Journal of Cancer. Journal International Du Cancer·Chelsea AndersonHazel B Nichols
Jul 3, 2018·Journal of Women's Health·Maria Vittoria DieciValentina Guarneri
Jan 13, 2018·Journal of the National Cancer Institute·Turkan Ozturk TopcuEllen Warner
Oct 10, 2018·Current Opinion in Oncology·Matteo LambertiniEvandro de Azambuja
Dec 27, 2018·Journal of Adolescent and Young Adult Oncology·Ahmad AmeriParisa Rashidi
Apr 11, 2019·Journal of Women's Health·Deborah Dinardo, Melissa McNeil
Dec 19, 2018·ESMO Open·Francesca PoggioLucia Del Mastro
Jul 4, 2019·The Oncologist·Mihong ChoiKyung-Hun Lee
Nov 27, 2019·The Oncologist·Shu-Chun ChuangChao Agnes Hsiung
Feb 21, 2019·Oncotarget·Matteo Lambertini, Giulia Viglietti
Jul 17, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matteo LambertiniHatem A Azim
Jul 7, 2018·Therapeutic Advances in Medical Oncology·Matteo B Suter, Olivia Pagani
Nov 30, 2019·Current Treatment Options in Oncology·Lorenzo RossiOlivia Pagani
Jan 13, 2018·Journal of the National Cancer Institute·Matteo LambertiniHatem A Azim
Mar 21, 2019·Current Opinion in Oncology·Margherita CondorelliSharon L Bober
Jan 15, 2020·Journal of Cancer Survivorship : Research and Practice·Ilana R Azulay ChertokEllen Warner
Apr 3, 2020·Breast Cancer Research and Treatment·Ingeborg J H VriensVivianne C G Tjan-Heijnen
Aug 12, 2020·Breast Cancer Research and Treatment·Yuzhu ZhangRui Xu
Nov 18, 2018·Frontiers in Pediatrics·Riccardo Davanzo
Oct 31, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hatem A AzimMatteo Lambertini
Dec 9, 2020·Human Reproduction·M CondorelliI Demeestere
Dec 18, 2020·Critical Reviews in Oncology/hematology·Petra VukovićMatteo Lambertini
Mar 23, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S Paluch-ShimonO Pagani
Nov 24, 2020·Human Reproduction Open·UNKNOWN ESHRE Guideline Group on Female Fertility PreservationNathalie Vermeulen
Jan 28, 2021·Human Reproduction Open·A FredrikssonA Strandell
Dec 15, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Rainer Souchon
Feb 12, 2020·The Oncologist·Shu-Chun ChuangChao Agnes Hsiung
Jun 18, 2020·Seminars in Oncology·Elaine M WalshVered Stearns
Mar 20, 2021·Journal of Assisted Reproduction and Genetics·Mary Kathryn AbelMitchell P Rosen
Apr 5, 2021·Lancet·Sibylle LoiblGiuseppe Curigliano
Feb 6, 2020·Bulletin du cancer·Antoine EliesRoman Rouzier
Apr 23, 2021·Breast Cancer Research and Treatment·Chloe LeprouxBaptiste Sauterey
May 15, 2021·American Society of Clinical Oncology Educational Book·Ines Vaz-LuisVered Stearns
Jun 2, 2021·Future Oncology·John R BensonIsmail Jatoi
Apr 7, 2021·Journal of the National Cancer Institute·Ke-Da YuUNKNOWN SPECTRUM Investigators

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.