Long-Term Single Center Experience in Treating Plaque Psoriasis With Guselkumab.

Journal of Cutaneous Medicine and Surgery
Khalad MaliyarMelinda J Gooderham

Abstract

Clinical trial data have shown guselkumab, an interleukin-23 inhibitor, to be efficacious and safe for the treatment of psoriasis. However, there is very little real-world experience using guselkumab in the community setting that has been documented. The goal of this study was to determine real-life outcomes of guselkumab use in patients with moderate-to-severe psoriasis in a community dermatology practice. A retrospective chart review of electronic medical records was conducted in patients with moderate-to-severe psoriasis who were prescribed guselkumab at a community dermatology office in Ontario, Canada. Of the 89 patients who received at least 1 dose of guselkumab, 79 had follow-up information at the time of review, with 71 patients receiving ongoing treatment. In our cohort of patients, 73.3% achieved clinically significant clearance of psoriasis with a global assessment of clear or almost clear defined as a body surface area involvement of <1%. Guselkumab was generally well tolerated and caused no serious adverse events. The most common reported side effects were nasopharyngitis, headaches, upper respiratory tract infections, gastrointestinal upset, and arthralgia. Overall, guselkumab was a safe and well-tolerated treatme...Continue Reading

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Citations

Dec 11, 2020·American Journal of Clinical Dermatology·Kevin YangBoni E Elewski
Jan 24, 2021·Dermatologic Therapy·Ricardo Ruiz-VillaverdeManuel Galán-Gutiérrez
Jul 25, 2020·The Journal of Dermatological Treatment·Matteo MegnaAngelo Ruggiero
Jul 23, 2021·American Journal of Clinical Dermatology·Marianne de Brito, Zenas Z N Yiu

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