Long-term stability of anti-cyclic citrullinated peptide antibody status in patients with early inflammatory polyarthritis.

Arthritis Research & Therapy
Marian L BurrAnne Barton

Abstract

The utility of reassessing anti-cyclic citrullinated peptide (anti-CCP) antibody status later in disease in patients presenting with early undifferentiated inflammatory polyarthritis, particularly in those who test negative for both anti-CCP and rheumatoid factor (RF) at baseline, remains unclear. We aimed therefore to determine the stability of CCP antibody status over time and the prognostic utility of repeated testing in subjects with early inflammatory polyarthritis (IP). Anti-CCP and RF were measured at baseline and 5 years in 640 IP patients from the Norfolk Arthritis Register, a primary care-based inception cohort. The relation between change in anti-CCP status/titer and the presence of radiologic erosions, the extent of the Larsen score, and Health Assessment Questionnaire (HAQ) score by 5 years was investigated. With a cut-off of 5 U/ml, 28% subjects tested positive for anti-CCP antibodies, 29% for RF, and 21% for both at baseline. Nine (2%) anti-CCP-negative patients seroconverted to positive, and nine (4.6%) anti-CCP-positive individuals became negative between baseline and 5 years. In contrast, RF status changed in 17% of subjects. However, change in RF status was strongly linked to baseline anti-CCP status and was ...Continue Reading

References

Apr 16, 2003·Annals of the Rheumatic Diseases·J VencovskýS Růzicková
Oct 15, 2003·Arthritis and Rheumatism·Solbritt Rantapää-DahlqvistWalther J van Venrooij
Oct 2, 2004·Annals of the Rheumatic Diseases·E LindqvistT Saxne
Jan 16, 2007·Annals of the Rheumatic Diseases·Pauline Y P C HoIan N Bruce
Jun 19, 2008·Arthritis Research & Therapy·Josef S SmolenOswald Wagner
Jan 21, 2009·Annals of the Rheumatic Diseases·V Nell-DuxneunerG Steiner

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Citations

Jan 24, 2013·Arthritis Research & Therapy·Nicola BizzaroUNKNOWN Forum Interdisciplinare per la Ricerca nelle Malattie Autoimmuni (FIRMA Group)

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