Long-term strength and functional status in inclusion body myositis and identification of trajectory subgroups.

Muscle & Nerve
Alexander G S OldroydJames A L Miller

Abstract

Objective information on longitudinal disease progression in inclusion body myositis (IBM) is lacking. Longitudinal dynamometry and functional status data were collated from a cohort of IBM patients. Annual change was calculated by means of linear modeling. Trajectories of change in grip, knee extension, IBM Functional Rating Scale (IBM-FRS) and Neuromuscular Symptom Score (NSS) were identified by means of latent growth mixture modeling. Data were collated from 75 IBM patients (348 person-years follow-up). Annual strength loss was greatest for pinch (-10%) and knee extension (-4%). Functional deterioration was greatest for males. Three distinct trajectory groups were identified. Rapid deterioration trajectory for grip strength was associated with younger diagnosis age. Rapid deterioration for knee extension strength was associated with older age of diagnosis. This study has quantified strength change in IBM and identified distinct trajectory groups, which will aid prognostication and stratification for inclusion into future clinical trials.

References

Nov 1, 1995·Annals of Neurology·R C GriggsL P Rowland
Feb 1, 2008·Muscle & Nerve·C E JacksonUNKNOWN Muscle Study Group
May 21, 2009·Brain : a Journal of Neurology·Marinos C DalakasAllan D Kirk
Jan 16, 2010·Neuromuscular Disorders : NMD·D Hilton-JonesM G Hanna
Mar 3, 2010·Annual Review of Clinical Psychology·Daniel S Nagin, Candice L Odgers
Jun 29, 2012·Neuromuscular Disorders : NMD·Yves AllenbachJean-Yves Hogrel
Mar 6, 2013·Annals of Neurology·Helma PlukGer J M Pruijn
Aug 12, 2016·Muscle & Nerve·Lindsay N AlfanoLinda P Lowes
Jan 27, 2017·Annals of the Rheumatic Diseases·J B LillekerUNKNOWN all UKMYONET contributors
Feb 12, 2017·Muscle & Nerve·Anders N JørgensenLouise P Diederichsen

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Citations

Apr 23, 2020·Muscle & Nerve·Hani Kushlaf
Sep 6, 2020·Current Opinion in Rheumatology·Latika Gupta, Hector Chinoy
Feb 19, 2021·Neurology·Bhaskar Roy, Robert C Griggs
Apr 15, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Gina SanghaPedro M Machado

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