Long-term stroke risk of single-fraction photon-based stereotactic radiosurgery for meningioma

Clinical Neurology and Neurosurgery
Shearwood McClellandJerry J Jaboin

Abstract

A recent randomized study of fractionated radiation therapy (RT) examining 44 subtotally resected/recurrent benign meningioma patients revealed that at median follow-up of 17.1 years, the risk of stroke following proton-photon RT was 20.5%; the average stroke developed 5.6 years following RT completion (Sanford et al., 2017). This stroke risk is up to 10 times higher than the 2-6% rate expected for the general population of ages 40-79 (Mozaffarian et al., 2015). The stroke rate following single-fraction stereotactic radiosurgery (SRS) has not been previously studied in meningioma patients. A PubMed database search for relevant articles examining SRS for meningioma with minimum mean/median follow-up of six years was undertaken. Stroke rate was assessed either from direct description in manuscripts, or from extrapolating post-SRS complications from reported clinical examinations (i.e. hemiparesis/weakness, pituitary dysfunction following treatment of cavernous sinus lesions). Results were then culled to determine an overall stroke rate. Fourteen studies met inclusion criteria; 1431 patients received photon-based SRS for meningioma with a sufficient long-term follow-up. Median/mean follow-up ranged from 75 to 144 months. Operative...Continue Reading

Citations

Jan 5, 2021·Journal of Neuro-oncology·Dimitri VanmarckeMaarten Lambrecht
May 15, 2021·International Journal of Radiation Oncology, Biology, Physics·Shearwood McClelland, Gordon A Watson
Jun 3, 2021·Cancers·Tamara IusMassimo Robiony

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