Long-term study of intraocular pressure changes in patients with human immunodeficiency virus treated with highly active antiretroviral therapy

Ophthalmology
Igor KozakWilliam R Freeman

Abstract

To characterize a longitudinal relationship between highly active antiretroviral therapy immune recovery as defined by an increase in CD4 cell counts and any associated changes in intraocular pressure (IOP) in both patients with and patients without a history of cytomegalovirus (CMV) retinitis and to determine if human immunodeficiency (HIV)-induced reduction in IOP is reversible. Retrospective analysis of patient data collected from 1997 through 2004. Cohort of patients from one eye center, including patients from the Longitudinal Study of Ocular Complications of Acquired Immunodeficiency Syndrome. Linear regression analyses were conducted within the CMV and non-CMV groups to determine the change in IOP per 100-unit change in CD4 count. Average changes in IOP per change in CD4 count were compared between the CMV and the non-CMV groups using a Wilcoxon rank-sum test. Linear regression analyses were conducted within the CMV and non-CMV groups to determine the linear relationship between the 12-month change in IOP per 12-month 100-unit change in CD4 count. Intraocular pressure in relation to changes in CD4 cell counts. Compared with the non-CMV group, the median IOP change per change in CD4 count was not statistically different f...Continue Reading

References

Mar 6, 1998·Archives of Ophthalmology·M P KaravellasW R Freeman
Jul 15, 1998·Current Eye Research·A S BankerW R Freeman
Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M A JacobsonE T Cunningham
Jan 5, 2002·American Journal of Ophthalmology·Douglas A JabsLarry D Hubbard
Aug 4, 2005·Retina·Daniel E GoldbergWilliam R Freeman

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Citations

Feb 16, 2008·International Journal of STD & AIDS·A NasoodiW W Dinsmore

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