Long-term supplementation of isomalto-oligosaccharides improved colonic microflora profile, bowel function, and blood cholesterol levels in constipated elderly people--a placebo-controlled, diet-controlled trial

Nutrition
Chi-Hua YenHsiao-Ling Chen

Abstract

The main purpose of this study was to determine the long-term (8 wk) effects of isomalto-oligosaccharide (IO) supplementation on fecal microflora, bowel function, and biochemical indicators of nutritional status in constipated elderly subjects. We also assessed whether the effect of IO was sustained after its withdrawal. Thirteen (five male) constipated subjects (age 82.5 ± 1.9 y) participated in this diet-controlled study that consisted of a 4-wk placebo period, two 4-wk IO (10 g/d) -supplementation periods (IO1 and IO2), and a 4-wk post period. Fasting blood was collected on the last day of each period. Stools were collected during the last week of each period. The bowel function was monitored throughout the study. The fecal bifidobacteria, lactobacilli, and bacteroides counts (log counts/g wet feces) significantly increased and clostridia count decreased at the end of the IO1 period. The effects were more pronounced in the IO2 period and then returned to the levels of the IO1 period at the end of the post period. Daily fecal excretion of acetate and propionate increased along with IO supplementation. The frequency of spontaneous defecation increased in the IO2 period, and wet fecal mass increased by 24% in both the IO1 and t...Continue Reading

Associated Clinical Trials

References

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Citations

Nov 20, 2013·Journal of Agricultural and Food Chemistry·Ting LiXingbin Yang
Feb 26, 2013·Journal of Gastroenterology and Hepatology·Mena Mustapha MazlynKhean-Lee Goh
Jul 23, 2014·Journal of Food Science·Damini KothariArun Goyal
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Jul 10, 2016·Journal of Molecular Biology·Darrell W Cockburn, Nicole M Koropatkin
Aug 24, 2016·Journal of Agricultural and Food Chemistry·Xiao Yan Chen, Michael G Gänzle
Oct 4, 2017·Canadian Journal of Dietetic Practice and Research : a Publication of Dietitians of Canada = Revue Canadienne De La Pratique Et De La Recherche En Diététique : Une Publication Des Diététistes Du Canada·Wendy J Dahl, Daniela Rivero Mendoza
Mar 18, 2020·Critical Reviews in Food Science and Nutrition·Muhammad BilalHairong Cheng
Apr 10, 2013·Letters in Applied Microbiology·Y HuM G Gänzle
May 28, 2019·Nutrients·Ghada A Soliman
Jan 30, 2021·Food Research International·Lesbia Cristina Julio-GonzalezOswaldo Hernandez-Hernandez
May 8, 2021·Applied Microbiology and Biotechnology·Cecelia A Garcia, Jeffrey G Gardner
Jun 6, 2021·Revista de gastroenterología de México·A T Abreu Y AbreuR Vázquez-Frias
Jun 20, 2021·Revista De Gastroenterología De México·A T Abreu Y AbreuR Vázquez-Frias
Oct 6, 2017·Journal of Agricultural and Food Chemistry·Nannan ZhaoSuiping Zheng
Oct 27, 2021·Critical Reviews in Food Science and Nutrition·Ayyappan Palaniappan, Mohammad Naushad Emmambux

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