PMID: 9527321Apr 4, 1998Paper

Long-term supplementation with alpha-tocopherol and beta-carotene and age-related cataract

Acta Ophthalmologica Scandinavica
J M TeikariO P Heinonen

Abstract

To study if long-term supplementation with alpha-tocopherol or beta-carotene is associated with cataract prevalence and severity. An end-of-trial random sample of 1828 participants from the randomized, double-blind, placebo-controlled clinical trial the alpha-tocopherol, beta-carotene cancer prevention study. The alpha-tocopherol, beta-carotene cancer prevention study was originally designed to examine whether supplementation with alpha-tocopherol or beta-carotene would reduce the incidence of lung cancer in male smokers. The participants for this study lived in Helsinki City or Uusimaa province and were at entry to the alpha-tocopherol, beta-carotene cancer prevention study 50 to 69 years old and smoked at least 5 cigarettes per day. They received alpha-tocopherol 50 mg/day, beta-carotene 20 mg/day, a combination of the two, or placebo supplements for 5 to 8 years (median 6.6 years). Outcome measures were: cortical, nuclear, and posterior subcapsular cataract, differentiated and quantified with lens opacity classification system (LOCS II). Lens opacity meter provided a continuous measure of cataract density. Supplementation with alpha-tocopherol or beta-carotene was not associated with the end-of-trial prevalence of nuclear (o...Continue Reading

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Citations

Nov 24, 2005·Eye·L Robman, H Taylor
Jun 15, 2012·The Cochrane Database of Systematic Reviews·Milan C MathewRichard M Davis
Mar 5, 2014·Nutrients·Li-Quan ZhaoEmptyyn Y The Epidemiological Evidence-Based Eye Disease Study Research Group
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Aug 3, 2021·Experimental Eye Research·Tayler F L WishartFrank J Lovicu

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