Long-term supplementation with young coconut juice does not prevent bone loss but rather alleviates body weight gain in ovariectomized rats

Biomedical Reports
Hiroshi MatsushitaA Wakatsuki

Abstract

Young coconut (Cocos nucifera Linn.) juice (YCJ) has traditionally been consumed to alleviate symptoms associated with the menopause. Recently, the authors demonstrated that short-term (6-week) YCJ supplementation to ovariectomized rats resulted in increased bone mass and bone formation parameter, suggesting that YCJ consumption has a positive effect on bone metabolism and may represent an intervention to help slow the bone loss during menopause transition. The present study sought to determine how long-term (12-week) YCJ supplementation affects bone metabolism in ovariectomized rats, to investigate whether such supplementation may be helpful to in osteoporosis treatment. Ten-week-old female Wistar rats were subjected to either a sham operation (Sham) or bilateral ovariectomy (Ovx). The Ovx+YCJ group received 5X-concentrated YCJ at a dose of 15 ml/kg/day for 12 weeks. Rats in the Ovx group had significantly lower femur bone mineral density than those in the Sham group. YCJ supplementation did not significantly affect this difference. However, YCJ prevented the increase in bone area of the mid third of the femur, a site high in cortical bone, and body weight gain observed following Ovx. Our findings indicate that long-term YCJ i...Continue Reading

References

Dec 1, 1991·Bone and Mineral·D N Kalu
Jun 13, 2001·JAMA : the Journal of the American Medical Association·D J Torgerson, S E Bell-Syer
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Aug 31, 2002·Endocrine Reviews·George WellsUNKNOWN Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group
Oct 2, 2003·JAMA : the Journal of the American Medical Association·Jane A CauleyUNKNOWN Women's Health Initiative Investigators
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Garnet L AndersonUNKNOWN Women's Health Initiative Steering Committee
Dec 3, 2005·The Journal of Clinical Investigation·Lawrence G Raisz
Jun 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rebecca D JacksonUNKNOWN Women's Health Initiative Investigators
Oct 10, 2008·Planta medica·Tawakalitu OseniV Craig Jordan
Jul 27, 2010·The Journal of Biological Chemistry·Muralimohan YepuruRamesh Narayanan
Jul 21, 2011·Asian Pacific Journal of Tropical Medicine·Manisha DebMandal, Shyamapada Mandal
Dec 1, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·David W DempsterA Michael Parfitt
Dec 14, 2012·BMC Complementary and Alternative Medicine·Nisaudah RadenahmadWinyou Mitranun
Jan 5, 2013·Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry·Kamal DuaAdinarayana Gorajana
Feb 8, 2014·Climacteric : the Journal of the International Menopause Society·Y OhyamaA Wakatsuki
Feb 17, 2015·Lancet·UNKNOWN Collaborative Group On Epidemiological Studies Of Ovarian CancerR Peto
Aug 19, 2015·Maturitas·Nadine M P Daan, Bart C J M Fauser
Sep 1, 2015·Endocrinology and Metabolism Clinics of North America·Rachael E Van PeltWendy M Kohrt
May 29, 2016·The Medical Clinics of North America·Kim M O'Connor

❮ Previous
Next ❯

Citations

Oct 10, 2018·Climacteric : the Journal of the International Menopause Society·S ShimizuA Wakatsuki
Feb 13, 2018·Biomedical Reports·Saki ShimizuAkihiko Wakatsuki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.