PMID: 6979722Jul 1, 1982Paper

Long-term suppression of central serotonergic activity by corticosteroids: a possible model of steroid-responsive myoclonic disorders

Neurology
P A NausiedaA Braun

Abstract

Chronic administration of cortisol succinate (12.5 mg per kilogram per day) to guinea pigs suppressed jumping behavior induced by 1-5 hydroxytryptophan and abolished diurnal threshold variations of this behavior. Chronic corticosteroid administration did not alter threshold or diurnal variations of apomorphine-induced stereotypy. These observations suggest that the efficacy of corticosteroids in some human myoclonic movement disorders may be related to central serotonergic inhibition.

Citations

Jan 22, 2004·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Richard A Hrachovy, James D Frost
Feb 4, 2005·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·James D Frost, Richard A Hrachovy
Jan 1, 1987·Epilepsia·R A HrachovyD G Glaze
Sep 1, 1988·Epilepsia·R A HrachovyD G Glaze
Jan 1, 1986·Neuropharmacology·M R Pranzatelli, S R Snodgrass
Jul 25, 2012·Neuroscience Research·R Lalonde, C Strazielle
Apr 1, 1984·Hospital Practice·G W Ellison
Sep 1, 1992·The International Journal of Neuroscience·R Sandyk

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