Long-term surgical outcome of masculinizing genitoplasty in large cohort of patients with disorders of sex development

The Journal of Urology
Maria Helena Palma SirciliBerenice Bilharinho de Mendonca

Abstract

We evaluated the results of masculinizing genitoplasty in a large cohort of patients with disorders of sex development treated at a single public tertiary center. We evaluated 52 patients with 46,XY and 7 with 46,XX disorders of sex development with proximal hypospadias and genital ambiguity reared as males who had undergone surgery between 1965 and 2008. Mean +/- SD followup was 14.1 +/- 9.2 years and median age at last examination was 22 years, with 38 patients having reached adulthood. Morphological result and urinary stream were evaluated by a physician. Urinary and sexual symptoms, and satisfaction with surgical results were assessed by questionnaire. Mean penile length at diagnosis was compared between 46,XY patients and showed that those with 5alpha-reductase 2 deficiency had the shortest penile length (-5.4 +/- 1.2 SD). At the last clinical evaluation following surgical and hormonal treatment mean +/- SD penile length in 38 adults was 7.5 +/- 2.1 cm (range 4 to 12), corresponding to -4.3 +/- 1.3 SD (-6.5 to -1.5). All but 2 patients had penile length less than -2 SD. At that time mean penile length remained shorter in patients with 5alpha-reductase 2 deficiency (-5.4 +/- 1 SD) compared to those with testosterone product...Continue Reading

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Citations

May 15, 2013·Journal of Pediatric Urology·Ali Tourchi, Piet Hoebeke
Mar 20, 2013·The Journal of Urology·Yvonne G van der ZwanUNKNOWN Dutch Study Group on DSD
Nov 28, 2012·Journal of Pediatric Urology·Justine SchoberChristopher Woodhouse
Nov 20, 2012·Journal of Pediatric Urology·Peter LeeChristopher Woodhouse
Nov 17, 2015·Endocrinology and Metabolism Clinics of North America·Gabriela GuercioRodolfo A Rey
Aug 26, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Nigel P MonganIeuan A Hughes
Jul 9, 2014·Orvosi hetilap·László SágodiLászló Barkai
May 26, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Berenice B MendoncaJean D Wilson
Apr 9, 2011·Nature Reviews. Urology·Marco Castagnetti, Alaa El-Ghoneimi
Apr 1, 2014·The Journal of Urology·Maria Helena Palma SirciliSorahia Domenice
Dec 7, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Rebecca M Harris, Yee-Ming Chan
Sep 9, 2018·Journal of Bioethical Inquiry·Limor Meoded Danon
Feb 15, 2019·Pediatric Surgery International·Takanori OchiAtsuyuki Yamataka
Oct 24, 2018·Endocrine Connections·Jin Kyu OhJae-Seung Paick
May 17, 2018·Archives of Endocrinology and Metabolism·Rafael Loch BatistaBerenice Bilharinho de Mendonca
Aug 1, 2019·Endocrine Reviews·Amy B WisniewskiBerenice B Mendonca

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