Long-term surgical outcomes following transsphenoidal surgery in patients with Rathke's cleft cysts

Journal of Neurosurgery
Michelle LinGabriel Zada

Abstract

Rathke's cleft cysts (RCCs) are benign epithelial lesions of the sellar region typically treated via a transsphenoidal approach with cyst fenestration and drainage. At present, there is limited evidence to guide patient selection for operative treatment. Furthermore, there is minimal literature describing factors contributing to cyst recurrence. The authors conducted a retrospective analysis of 109 consecutive cases of pathology-confirmed RCCs treated via a transsphenoidal approach at a single center from 1995 to 2016. The majority of cases (86.2%) involved cyst fenestration, drainage, and partial wall resection. Long-term outcomes were analyzed. A total of 109 surgeries in 100 patients were included, with a mean follow-up duration of 67 months (range 3-220 months). The mean patient age was 44.6 years (range 12-82 years), and 73% were women. The mean maximal cyst diameter was 14.7 mm. Eighty-eight cases (80.7%) were primary operations, and 21 (19.3%) were reoperations. Intraoperative CSF leak repair was performed in 53% of cases and was more common in reoperation cases (71% vs 48%, p < 0.001). There were no new neurological deficits or perioperative deaths. Two patients (1.8%) developed postoperative CSF leaks. Transient diabet...Continue Reading

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Citations

Mar 25, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Joshua A LeeDavid A Gudis
Jan 4, 2020·Experimental and Therapeutic Medicine·Shousen WangLiangfeng Wei
Jul 27, 2021·Journal of Neurological Surgery. Part B, Skull Base·Leopold ArkoTheodore H Schwartz

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Methods Mentioned

BETA
biopsies
light microscopy
biopsy

Software Mentioned

REDCap

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