Long-term surgical outcomes in congenital diaphragmatic hernia: observations from a single institution

Journal of Pediatric Surgery
Tim JancelewiczKerilyn K Nobuhara

Abstract

Surgical complications are common in survivors of congenital diaphragmatic hernia (CDH), but little is known about long-term incidence patterns and associated predictors. A cohort of 99 CDH survivors was prospectively followed at a single-institution multidisciplinary clinic. Data were gathered regarding the adverse surgical outcomes of hernia recurrence, chest and spinal deformity, and operative small bowel obstruction (SBO), and then were retrospectively analyzed in relation to perinatal and perioperative markers of disease severity to determine significant predictors. Statistical methods used included univariate and multivariate regression analysis, hazard modeling, and Kaplan-Meier analysis. At a median cohort age of 4.7 (range, 0.2-10.6) years, 46% of patients with patch repairs and 10% of those with primary repairs had a hernia recurrence at a median time of 0.9 (range, 0.1-7.3) years after repair. Chest deformity was detected in 47%. Small bowel obstruction and scoliosis occurred in 13%. Recurrence and chest deformity were significantly more common with patch repair, liver herniation, age at neonatal extubation greater than 16 days, oxygen requirement at discharge, and prematurity. The strongest predictor of SBO was patc...Continue Reading

References

Feb 1, 1994·Journal of Pediatric Surgery·D P LundJ M Wilson
Jan 1, 1996·Journal of Pediatric Surgery·A P MetkusN S Adzick
Jun 1, 1996·Journal of Pediatric Surgery·K VanamoI Louhimo
Jul 30, 2005·Seminars in Perinatology·Sonlee D West, Jay M Wilson
Aug 6, 2005·Journal of Pediatric Surgery·George W HolcombKelly A Miller
Jan 18, 2006·Journal of Pediatric Surgery·Erich J GrethelKerilyn K Nobuhara
Aug 23, 2006·Hernia : the Journal of Hernias and Abdominal Wall Surgery·A GuptaA Keshishian
Apr 28, 2007·Seminars in Pediatric Surgery·Pietro Bagolan, Francesco Morini
May 19, 2007·The Journal of Surgical Research·Shawn D St PeterCharles L Snyder
Sep 4, 2007·Pediatrics·UNKNOWN Congenital Diaphragmatic Hernia Study GroupRonald B Hirschl
Mar 4, 2008·Pediatrics·Kevin P LallyWilliam Engle
Jun 14, 2008·Prenatal Diagnosis·Priscilla Chiu, Holly L Hedrick
Oct 22, 2008·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Uberto FumagalliRiccardo Rosati

❮ Previous
Next ❯

Citations

Sep 21, 2011·Pediatric Surgery International·P KuklováM Rygl
Oct 24, 2012·Pediatric Surgery International·Massimo GarriboliAgostino Pierro
Jul 25, 2012·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Shaun M KunisakiGeorge B Mychaliska
Aug 7, 2012·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Elizabeth B Froh, Diane L Spatz
Apr 12, 2012·Current Opinion in Pediatrics·Michael D Rollins
Jan 15, 2014·Journal of Radiology Case Reports·Bhanumathi LakshminarayananKokila Lakhoo
Jan 10, 2012·ISRN Surgery·Emeka B Kesieme, Chinenye N Kesieme
Dec 3, 2014·Seminars in Pediatric Surgery·Bhanumathi LakshminarayananHugh W Grant
Oct 13, 2014·Seminars in Fetal & Neonatal Medicine·Sarah Tracy, Catherine Chen
Oct 1, 2013·Journal of Pediatric Surgery·Kamal AliAnne Greenough
Jan 17, 2012·Journal of Pediatric Surgery·Douglas C BarnhartMichael D Rollins
Jun 7, 2011·Early Human Development·Enrico Danzer, Holly L Hedrick
May 24, 2011·Journal of Tissue Engineering and Regenerative Medicine·Katrien M BrouwerToin H van Kuppevelt
Apr 14, 2012·Prenatal Diagnosis·Rebekah A SamangayaAntonino Morabito
May 17, 2012·Journal of Tissue Engineering and Regenerative Medicine·Katrien M BrouwerRené M Wijnen
Nov 15, 2013·The British Journal of Surgery·W B JawaidP D Losty
Sep 9, 2015·Pediatric Pulmonology·Montaha M Al-IedeDominic A Fitzgerald
May 21, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Katrien M BrouwerToin H van Kuppevelt
Feb 26, 2016·Pediatric Surgery International·Elin ÖstBjörn Frenckner
Mar 25, 2015·Pediatric Surgery International·Johannes W DuessMichael E Hoellwarth
Apr 14, 2012·Journal of Pediatric Surgery·Jacqueline TsaiAlan W Flake
Jun 4, 2014·Journal of Pediatric Surgery·Katie W RussellEric R Scaife
Jan 15, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Hajime TakayasuUNKNOWN Japanese Congenital Diaphragmatic Hernia Study Group
May 11, 2017·Journal of Pediatric Gastroenterology and Nutrition·Lan T VuHanmin Lee
Jan 4, 2018·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Heather L ShortAvraham Schlager
Sep 8, 2018·Journal of Neurosurgery. Spine·Sarah F EbyUNKNOWN Children’s Spine Study Group
May 21, 2017·Pediatric Surgery International·Elin ÖstMaria Öjmyr-Joelsson
Sep 21, 2017·Stem Cells International·G P LiaoY Li
Feb 20, 2020·Pediatric Surgery International·Eimear Kirby, Richard Keijzer
Nov 28, 2020·Pediatric Surgery International·Irene de Haro JorgeXavier Tarrado
Jan 29, 2021·Journal of Applied Physiology·Matthew J FogartyGary C Sieck
Mar 23, 2021·Journal of Pediatric Surgery·Camila Gonzalez RuhrnschopfMarcelo Barrenechea
Jul 25, 2021·BMJ Case Reports·Kevin C McGannMichael H Livingston
Oct 2, 2017·Journal of Pediatric Surgery·Sandra K KabagambeAijun Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.