Long-term survival after acute myocardial infarction and relation to type 2 diabetes and other risk factors.
Abstract
Diabetes mellitus (DM) is well established as a short-term prognostic indicator after myocardial infarction (MI), but little long-term data are available. The objective of the study was to assess the impact of DM and other patient characteristics at baseline on long-term mortality after acute MI. Patients who were hospitalized with MI from December 1990 to November 1992 were recruited. Baseline data were recorded and patients were followed up through January 31, 2008, to assess their survival rates. Survival curves were generated by the Kaplan-Meier method. The main outcome measure was long-term survival (median 16.6 y). The study followed 337 patients (mean age 66.4 y, 61.1% men) for a median of 16.6 years. Using Cox regression analysis, survival was associated with history of MI (hazard ratio [HR]: 1.47, P = 0.016), DM at baseline (HR: 1.31, P = 0.038), and age (HR: 1.061 for each additional year, P < 0.001). By multivariable regression, cardiovascular mortality was also associated with previous MI (HR: 1.58, P = 0.017), DM at baseline (HR: 1.69, P = 0.001), and age (HR: 1.075 for each additional year, P < 0.001). There was no statistically significant difference between the HRs for history of MI and history of DM. Diabetic p...Continue Reading
References
Citations
Related Concepts
Related Feeds
CV Disorders & Type 2 Diabetes
This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.
Cardiovascular Disease Pathophysiology
Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.
Cardiovascular Disorder in Diabetes
Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.