Long-term survival after combined modality treatment in metastatic bladder cancer patients presenting with supra-regional tumor positive lymph nodes only

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
R R de VriesS Horenblas

Abstract

To evaluate if combined treatment should be offered to bladder cancer patients presenting with supra-regional lymph node metastases only and a clinical complete or partial response after chemotherapy. We identified 14 patients with supra-regional lymph node metastases out of 394 patients with transitional cell carcinoma (TCC) treated in our institute with cystectomy and regional and supra-regional lymph node dissection between 1987 and 2007. Prior to cystectomy, neoadjuvant chemotherapy had been given. The patients received a total of four cycles of platinum-based chemotherapy. Five patients had a CR, nine patients had a PR after neoadjuvant chemotherapy. Histopathological proof of complete response in the bladder was confirmed in all five cases. One of these five patients had a CR in the bladder but pelvic lymph nodes still contained vital tumor. Five patients had no tumor in the lymph nodes, whereas four had tumor in the lymph nodes. Eleven patients died due to bladder cancer, seven of them within 1 year after cystectomy. The 3- and 5-year disease-specific survival rates were 36% (95% CI: 10-60%) and 24% (95% CI: 0-49%). Mean follow-up was 2.5 years. Combination therapy consisting of neoadjuvant chemotherapy and surgery in se...Continue Reading

References

Jul 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans von der MaaseMichael Arning
Apr 18, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P TherasseJ Verweij

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Citations

Nov 20, 2013·Urology·Richard P MeijerSimon Horenblas
Oct 5, 2013·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·Y NeuzilletUNKNOWN les membres du Comité de cancérologie de l’Association française d’urologie
Feb 5, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R P MeijerS Horenblas
Aug 23, 2011·Scandinavian Journal of Urology and Nephrology·Jørgen Bjerggaard JensenKlaus Møller-Ernst Jensen
Jun 9, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas SeisenQuoc-Dien Trinh
Aug 24, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew D GalskyBart S Ferket
Dec 4, 2009·Expert Review of Anticancer Therapy·Faysal A Yafi, Wassim Kassouf
Mar 9, 2012·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Avishay Sella, Svetlana Kovel
Jul 30, 2016·Current Opinion in Urology·Takashige AbeNobuo Shinohara

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