Long-term survival and cure model following liver resection for breast cancer metastases

Breast Cancer Research and Treatment
Aldrick RuizR Adam

Abstract

Long-term survival is still rarely achieved with current systemic treatment in patients with breast cancer liver metastases (BCLM). Extended survival after hepatectomy was examined in a select group of BCLM patients. Hepatectomy for BCLM was performed in 139 consecutive patients between 1985 and 2012. Patients who survived < 5 years were compared to those who survived ≥ 5 years from first diagnosis of hepatic metastases. Predictive factors for survival were analyzed. Statistically cured, defined as those patients who their hazard rate returned to that of the general population, was analyzed. Of the 139, 43 patients survived ≥ 5 years. Significant differences between patient groups (< 5 vs. ≥ 5 years) were mean time interval between primary tumor and hepatic metastases diagnosis (50 vs. 43 months), mean number of resected tumors (3 vs. 2), positive estrogen receptors (54% vs. 79%), microscopic lymphatic invasion (65% vs. 34%), vascular invasion (63% vs. 37%), hormonal therapy after resection (34% vs. 74%), number of recurrence (40% vs. 65%) and repeat hepatectomy (1% vs. 42%), respectively. The probability of statistical cure was 14% (95% CI 1.4-26.7%) in these patients. Hepatectomy combined with systemic treatment can provide a...Continue Reading

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Citations

Jun 24, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·X HeL Wang
Sep 11, 2019·Journal of Surgical Oncology·Francesca RattiLuca Aldrighetti
Dec 18, 2020·Seminars in Interventional Radiology·Ariel N Liberchuk, Amy R Deipolyi
Apr 10, 2021·Statistical Methods in Medical Research·Xiaoxiao Zhou, Xinyuan Song

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Methods Mentioned

BETA
surgical resection
dissection

Software Mentioned

STATA
SPSS

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