Long-term survival and disease recurrence following portal vein embolisation prior to major hepatectomy for colorectal metastases

Annals of Surgical Oncology
Viniyendra PamechaBrian Davidson

Abstract

Portal vein embolisation (PVE) can be used to increase the remnant liver parenchyma volume before major hepatectomy but may stimulate tumour growth. The pattern of disease recurrence and long-term survival has not been adequately addressed. Over a period of 7 years 36 patients underwent preoperative PVE before resection of four or more liver segments for colorectal cancer (CRC) liver metastases. PVE was performed when the future liver remnant (FLR) assessed by magnetic resonance imaging (MRI) scan volumetry was less than 30%. Disease-free and overall survival was compared with a control group (65 patients) undergoing extended right/right hepatectomy for CRC metastases without PVE during the same time period. PVE was successful in all patients. PVE increased the median FLR volume by 37% [295 ml (22%) to 404 ml (32%), p < 0.0001]. 61% of patients undergoing PVE proceeded to liver resection (n = 22). Twelve patients (33%) developed disease progression following PVE. The 5-year survival after liver resection with PVE was 25%, compared with 50% without PVE. The 5-year disease-free survival was 30% post PVE and 50% without PVE. We conclude that PVE significantly increases the future liver remnant. Only two-thirds of patients proceed ...Continue Reading

References

Oct 1, 1986·World Journal of Surgery·H KinoshitaS Kubo
Feb 24, 2001·Journal of the American College of Surgeons·J MelendezL H Blumgart
Aug 2, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N KokudoY Kato
Jan 14, 2005·Gut·M J SchindlUNKNOWN Edinburgh Liver Surgery and Transplantation Experimental Research Group (eLISTER)
Jan 26, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P LindnérM Rizell
Mar 1, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Diane GoéréJacques Belghiti
Jun 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eddie K Abdalla, Jean-Nicolas Vauthey
Jan 16, 2007·World Journal of Surgery·J C HewesB R Davidson
Feb 23, 2007·The British Journal of Surgery·D ZorziE K Abdalla
May 4, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sander DinantThomas M van Gulik
Jun 7, 2007·World Journal of Surgery·Alessandro FerreroLorenzo Capussotti
Mar 15, 2008·Cancer·Dan S Zuckerman, Jeffrey W Clark

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Citations

Mar 29, 2014·Indian Journal of Surgical Oncology·Soumil VyasHemant M Kocher
Jul 19, 2012·Cardiovascular and Interventional Radiology·K P van LiendenO M van Delden
Oct 8, 2011·Cardiovascular and Interventional Radiology·Maarten L J SmitsLuc Defreyne
Jun 22, 2014·Current Treatment Options in Oncology·Michael A Choti
Jan 31, 2013·Radiology·Andreas H MahnkenThierry de Baère
Mar 10, 2010·Langenbeck's Archives of Surgery·Kia HomayounfarB Michael Ghadimi
Feb 23, 2013·World Journal of Gastroenterology : WJG·De-Bang LiYan-Ming Zhou
Dec 6, 2012·World Journal of Surgery·Suguru YamashitaNorihiro Kokudo
Aug 5, 2011·British Medical Bulletin·Robert P Sutcliffe, Satyajit Bhattacharya
Jul 16, 2009·Annals of Surgical Oncology·Viniyendra Pamecha, Brian Davidson
Apr 10, 2013·Nature Reviews. Gastroenterology & Hepatology·Chetana LimMarc Pocard
Mar 3, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Lidewij SpeltChristian Sturesson
Dec 13, 2012·ANZ Journal of Surgery·Samuel C L KuoThomas J Hugh
Feb 13, 2014·Journal of Hepato-biliary-pancreatic Sciences·Ryota Higuchi, Masakazu Yamamoto
Apr 4, 2016·Advances in Therapy·Joseph Ralph KalliniRobert J Lewandowski
Jun 11, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G K GlantzounisG Pentheroudakis
Feb 12, 2009·British Journal of Cancer·V PamechaB R Davidson
May 29, 2012·Scandinavian Journal of Gastroenterology·Lidewij SpeltRoland Andersson
Sep 22, 2017·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·José Hugo Mendes LuzTiago Nepomuceno de Miranda
Mar 28, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Dongda SongWeichang Guo
Jun 10, 2020·Cardiovascular and Interventional Radiology·I KurilovaF M Gomez
Mar 12, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Lilian SchwarzEric Vibert

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