Long-term survival and loss in expectancy of life in a population-based cohort of 7114 patients with diffuse large B-cell lymphoma

American Journal of Hematology
Sara EkbergKarin E Smedby

Abstract

Survival has improved among patients with diffuse large B-cell lymphoma (DLBCL) with the addition of anti-CD20 antibody therapy. We aimed to quantify trends and remaining loss in expectation of life (LEL) due to DLBCL at a national population-based level. Patients diagnosed with DLBCL 2000-2013 (N=7114) were identified through the Swedish Lymphoma Registry and classified according to the age-adjusted International Prognostic Index (aaIPI).The novel measure LEL is the difference between remaining life years among patients and the general population and was predicted using flexible parametric models from diagnosis and among 2-year survivors, by age and sex. Median age at DLBCL-diagnosis was 70 (range 18-105) years and 54.8% presented with stage III-IV disease. On average, LEL due to DLBCL decreased from 8.0 (95%CI 7.7-8.3) to 4.6 (95%CI 4.5-4.6) years over the study period. By risk group, LEL was most reduced among patients with aaIPI≥2 aged 50-60 years. However, these patients were still estimated to lose >8 years in 2013 (e.g., LELmales50years 8.6 years (95%CI 5.0-12.3)). Among 2-year survivors, LEL was reduced from 6.1 years (95%CI 5.6-6.5) (aaIPI≥2) and 3.8 years (95%CI 3.6-4.1) (aaIPI<2) to 1.1 (95%CI 1.1-1.2) and 1.0 year (...Continue Reading

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Citations

Mar 15, 2020·Calcified Tissue International·Peter JohanssonCatharina Lewerin
Sep 29, 2020·International Journal of Epidemiology·Luigino Dal MasoUNKNOWN EUROCARE-5 Working Group
Jun 11, 2021·Journal of Internal Medicine·O Landgren

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