Long-term survival following minimally invasive extended cholecystectomy for gallbladder cancer: A 7-year experience from the National Cancer Database

Journal of Surgical Oncology
Samer AlMasriAlessandro Paniccia

Abstract

Open extended cholecystectomy (O-EC) has long been the recommended treatment for resectable gallbladder cancer (GBC), while the minimally-invasive approach for EC (MIS-EC) remains controversial. Our aim was to analyze overall survival of GBC patients treated with MIS-EC vs O-EC at the national level. A retrospective review of the National Cancer Database of patients with resectable GBC (2010-2016) and treated with either MIS-EC or O-EC was performed. Overall survival (OS) was compared by the surgical approach. A total of 680 patients were identified, of whom 235 (34.6%) underwent MIS-EC. There were no differences in the rates of positive margins between MIS-EC and O-EC (14% vs 19%, respectively; P = .278), and in the mean lymph node yield (6.54 vs 6.66, respectively; P = .914). The median survival following MIS-EC was significantly higher than that of O-EC (39 vs 26 months; P = .048). After stratification by pathological stage and after adjustment, there was no significant difference in OS between the groups (HR = 0.9, 95% CI, 0.6-1.5). In this large national cohort, MIS-EC oncologic outcomes were noninferior to the O-EC. Proficiency with MIS techniques, proper patient selection, and referral to specialized centers may allow a ...Continue Reading

References

Mar 16, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y P Reddy, W G Sheridan
Apr 17, 2002·Journal of Hepato-biliary-pancreatic Surgery·V Paolucci
May 26, 2006·Journal of Surgical Oncology·Ralf SteinertMarc-André Reymond
Aug 30, 2008·Journal of the American College of Surgeons·Natalie G CoburnCalvin H L Law
Sep 20, 2008·Journal of Surgical Oncology·A DuffyE M O'Reilly
Dec 17, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Eric H JensenTodd M Tuttle
Jan 18, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Ketao JinLisong Teng
Jan 20, 2011·World Journal of Gastroenterology : WJG·Seung Eun LeeSun-Whe Kim
Sep 25, 2012·World Journal of Gastroenterology : WJG·Yoshio ShiraiKatsuyoshi Hatakeyama
Mar 26, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M D'HondtF Vandenbroucke-Menu
May 15, 2013·Journal of Visceral Surgery·D FuksO Farges
Mar 19, 2014·Clinical Epidemiology·Rajveer Hundal, Eldon A Shaffer
Oct 12, 2014·Surgical Endoscopy·Takashi Shirobe, Shotaro Maruyama
Mar 6, 2015·Surgical Endoscopy·Osamu ItanoYuko Kitagawa
May 13, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edgar Ben-JosefCharles D Blanke
Jun 14, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·S Jane HenleyLisa C Richardson
Aug 15, 2015·Journal of the American College of Surgeons·Yoo-Seok YoonHanlim Choi
Sep 30, 2015·Surgical Endoscopy·Senthilnathan PalanisamyPalanivelu Chinnusamy
Jan 18, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Francesco GuerraAndrea Coratti
Aug 20, 2016·OncoTargets and Therapy·Tadeusz DorobiszDariusz Janczak
Aug 22, 2017·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Naeem GoussousSteven C Cunningham
Oct 5, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Rachel E Beard, Allan Tsung
Jan 18, 2018·Digestive Surgery·Ho-Seong HanRoberto I Troisi
Feb 24, 2018·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Cecilia T OngMathias Worni
Dec 26, 2018·The British Journal of Surgery·K SøreideS J Wigmore
Feb 26, 2019·Journal of Surgical Oncology·Mahesh GoelSagar Kurunkar
Oct 12, 2019·Journal of Minimal Access Surgery·Hirdaya Hulas NagPhani Kumar Nekarakanti

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Citations

Sep 16, 2021·Current Treatment Options in Oncology·Kimberly Washington, Flavio Rocha

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