Long-term survival in children with atrioventricular septal defect and common atrioventricular valvar orifice in Sweden

Cardiology in the Young
Christina FridBo Lundell

Abstract

The survival for patients with atrioventricular septal defect has improved markedly over the last decades and, during the same period, the survival of children with Down's syndrome has also increased. The aim of our study was to investigate long-term survival in patients having atrioventricular septal defect with common valvar orifice, but without associated significant congenital heart defects, in the setting of Down's syndrome, comparing the findings to those in chromosomally normal children with the same malformation. In a population-based retrospective study, we scrutinised the medical records from 801 liveborn children with atrioventricular septal defect born in Sweden during the period 1973 through 1997. Data on gender, presence or absence of Down's syndrome, associated congenital heart defects, date of birth, operation and death were recorded and followed up until 2001. An isolated atrioventricular septal defect with common atrioventricular valvar orifice was present in 502 children, of whom 86% had Down's syndrome. We found a significant reduc tion over time in age at operation, and in postoperative mortality at 30 days, from 28 to 1%. Using a multiple logistic regression model, we found no significant differences in mo...Continue Reading

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Citations

Jun 10, 2006·Scandinavian Journal of Public Health. Supplement·Anders Hjern
Sep 21, 2005·Genetics·Randall J RoperRoger H Reeves
Mar 17, 2010·The Journal of Pediatrics·Assia MillerAdolfo Correa
Apr 5, 2013·Birth Defects Research. Part A, Clinical and Molecular Teratology·Attila VereczkeyAndrew E Czeizel
Feb 26, 2013·American Journal of Medical Genetics. Part a·Annika EnglundGöran Annerén
Sep 11, 2014·PloS One·Rachel L KnowlesUNKNOWN UKCSCHD (UK Collaborative Study of Congenital Heart Defects) collaborators
Jun 18, 2016·Journal of the American Heart Association·Kate E Best, Judith Rankin
Mar 24, 2007·Prenatal Diagnosis·Kavitha ChintalaSanjeev Aggarwal
Jul 9, 2004·Cardiology in the Young·Tjark Ebels, J William Gaynor
Feb 17, 2015·Cardiology in the Young·Jeannie VisootsakJessica Hunter
Sep 29, 2005·Acta Paediatrica·Alf MebergErik Thaulow

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