Long-term survival in hilar cholangiocarcinoma also possible in unresectable patients.

World Journal of Surgery
A T RuysThomas Mathijs van Gulik

Abstract

Radical resection remains the only curative treatment for hilar cholangiocarcinoma (HCCA). Only a limited proportion of patients, however, are eligible for resection. The survival and prognostic factors of these patients are largely unknown. The aim of this study was to evaluate survival and prognostic factors in unresectable patients presenting with HCCA. We performed a cohort study of the denominator of HCCA patients seen in a tertiary referral center between March 2003 and March 2009. Demographics, treatment, pathology results, and survival were analyzed. A total of 217 patients with suspected HCCA were identified. Ninety-five patients (40 %) underwent laparotomy, and in 57 (63 %) of these patients resection was performed. Overall median and 5-year survival of resected patients were 37 months and 43 %, respectively, as compared to 13 months and 7 % in unresectable patients. In unresectable patients, median survival was better in patients with locally advanced disease (16 months) as compared to patients with hepatic and extrahepatic metastases (5 and 3 months, p < 0.001). Of the 160 unresectable patients, 17 (10 %) survived longer than 3 years. Of the patients presenting with HCCA in our center, 26 % proved resectable. The 7 ...Continue Reading

References

Dec 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T R KurzawinskiB R Davidson
Sep 27, 2001·Annals of Surgery·W R JarnaginL H Blumgart
Oct 31, 2002·Surgery·Attila NakeebHenry A Pitt
Apr 26, 2005·Annals of Surgery·William R JarnaginLeslie H Blumgart
Apr 15, 2006·Annals of Surgical Oncology·Sander DinantThomas M van Gulik
Dec 19, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S ConnorO J Garden
Sep 6, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·J J KloekT M van Gulik
Jul 30, 2009·Annals of Surgery·Fumito ItoSharon M Weber
Sep 17, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jaap J KloekThomas M van Gulik
Oct 7, 2009·Journal of Hepato-biliary-pancreatic Sciences·Tsuyoshi IgamiMasato Nagino
Jan 19, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wilmar de GraafRoelof J Bennink
Apr 9, 2010·The New England Journal of Medicine·Juan ValleUNKNOWN ABC-02 Trial Investigators
Dec 1, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T M van GulikD J Gouma
Feb 25, 2011·Annals of Surgical Oncology·Anthony T RuysThomas M van Gulik
Mar 23, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Anthony T RuysThomas M van Gulik
Apr 13, 2011·The British Journal of Surgery·W de GraafT M van Gulik

❮ Previous
Next ❯

Citations

Jul 19, 2013·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·Anthony T RuysThomas M van Gulik
Jan 29, 2013·World Journal of Surgery·Jin Hong LimWoo Jung Lee
Nov 23, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D GomezH Z Malik
Jul 3, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ali SiddiquiDouglas G Adler
Sep 17, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Anthony T RuysThomas M van Gulik
Apr 18, 2015·World Journal of Surgical Oncology·Takehiro NojiSatoshi Hirano
Mar 21, 2015·AJR. American Journal of Roentgenology·Marc Rudi EngelbrechtOtto M van Delden
Nov 8, 2014·International Journal of Colorectal Disease·Shuai XiangXiao-Ping Chen
May 11, 2017·The British Journal of Surgery·T EbataM Nagino
Sep 10, 2020·Annals of Surgical Oncology·Jaynee J A VugtsStefan Buettner
Sep 3, 2016·Science China. Life Sciences·Binhao ZhangXiao-Ping Chen
Sep 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Sirintip BoonjaraspinyoPanaratana Ratanasuwan
Feb 14, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Marcia P GasperszFrançois E J A Willemssen
May 17, 2017·United European Gastroenterology Journal·Pim B OlthofThomas M van Gulik
Mar 9, 2017·Abdominal Radiology·Irai S OliveiraKarthik Ganesan
Jan 24, 2020·Current Medicinal Chemistry·Angela LamarcaJuan W Valle
Jan 26, 2021·International Cancer Conference Journal·Takeshi SakataMasayuki Sho
Sep 2, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ola AhmedM B M Doyle
Jul 30, 2017·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Marcia P GasperszBas Groot Koerkamp

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.