PMID: 8959676Nov 1, 1996Paper

Long-term survival in small cell lung cancer: the case for a standard definition. Medical Research Council Lung Cancer Working Party

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
R J StephensD Machin

Abstract

This paper investigates whether a particular time point can be recommended as the standard definition for long-term survival (LTS) in small cell lung cancer (SCLC). A review of the literature specifically referring to long-term survival in SCLC in the title. Individual and updated survival data from 2196 patients entered into six Medical Research Council (MRC) SCLC randomised trials to investigate changes in the hazard, or risk of death, over time. Examination of subgroups to identify different hazard patterns. World-wide literature and patients recruited to SCLC trials conducted by the MRC Lung Cancer Working Party (LCWP). Papers accessed through computerised literature and hand searches and 2196 patients from six randomised clinical trials in SCLC conducted by the MRC LCWP. In all, 111 publications were identified by the literature searches. Although the majority defined LTS as 2 years, the definitions ranged from 18 months to greater than 5 years. There thus appears to be no agreed standard definition. The daily hazard was plotted for the large series of patients entered into the MRC LCWP SCLC trials to observe any patterns of change. There was an approximately constant daily hazard of 0.0035 during the first 2 years from ra...Continue Reading

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Citations

Oct 18, 2005·Lancet·David M Jackman, Bruce E Johnson
Sep 12, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·C R ThomasD R Gandara
Apr 25, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tadeusz Lewiński, Maciej Zuławski
Jul 3, 2009·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Nnamdi NwaejikeGianfranco Campalani
Aug 4, 2011·Equine Veterinary Journal. Supplement·D C ArcherC J Proudman
Jan 1, 1997·Clinical Oncology : a Journal of the Royal College of Radiologists·D MachinJ B Whaley
Oct 9, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Olivia Le SauxNaoual Bakrin
Apr 3, 2003·Congestive Heart Failure·Cheryl L DischerT Barry Levine
Aug 1, 1997·Australian and New Zealand Journal of Medicine·A Keogh

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