Long-term survival in young and middle-aged Hodgkin lymphoma patients in Sweden 1992-2009-trends in cure proportions by clinical characteristics

American Journal of Hematology
Ingrid GlimeliusSandra Eloranta

Abstract

Trends in Hodgkin lymphoma (HL) survival among patients treated outside of clinical trials provide real-world benchmark estimates of prognosis and help identify patient subgroups for targeted trials. In a Swedish population-based cohort of 1947 HL patients diagnosed in 1992-2009 at ages 18-59 years, we estimated relative survival (RS), cure proportions (CP), and median survival times using flexible parametric cure models. Overall, the CP was 89% (95% CI: 0.87-0.91) and median survival of the uncured was 4.6 years (95% CI: 3.0-6.3). For patients aged 18-50 years diagnosed after the year 2000, CP was high and stable, whereas for patients of 50-59 years, cure was not reached. The survival of relapse-free patients was similar to that of the general population (RS5-year : 0.99; 95% CI: 0.98-0.99, RS15-year : 0.95; 95% CI: 0.92-0.97). The excess mortality of relapsing patients was 19 times (95% CI: 12-31) that of relapse-free patients. Despite modern treatments, patients with adverse prognostic factors (e.g., advanced stage) still had markedly worse outcomes [CP stage: IIIB 0.82 (95% CI: 0.73-0.89); CP stage: IVB 0.72, (95% CI: 0.60-0.81)] and patients with international prognostic score (IPS) ≥3 had 2.7 times higher excess mortality...Continue Reading

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Citations

Dec 20, 2016·Journal of Internal Medicine·I Glimelius, A Diepstra
Feb 19, 2017·International Journal of Cancer. Journal International Du Cancer·Kathrine RugbjergJørgen H Olsen
Jul 26, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Caroline E WeibullIngrid Glimelius
Jan 23, 2019·International Journal of Cancer. Journal International Du Cancer·Caroline E WeibullSandra Eloranta
Feb 7, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jorne Lionel BicclerKarin E Smedby
Aug 7, 2017·Current Hematologic Malignancy Reports·Natalie S Grover, Barbara Savoldo
Jul 24, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carlos A RamosBarbara Savoldo
Jul 11, 2020·The American Journal of Surgical Pathology·Ashley VolaricAlejandro A Gru
Mar 8, 2019·BMC Cancer·Natalie S Grover, Barbara Savoldo
Oct 17, 2019·Frontiers in Oncology·Sakthi RajendranHerbert Schwarz
Feb 9, 2021·Statistics in Medicine·Caroline E WeibullMichael J Crowther
Jul 11, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Amy M BerkmanMichael E Roth

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