Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways

Nature Medicine
Kenneth CardonaChristian P Larsen

Abstract

We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in pancreatectomized rhesus macaques. Although porcine islets transplanted into nonimmunosuppressed macaques were rapidly rejected by a process consistent with cellular rejection, recipients treated with a CD28-CD154 costimulation blockade regimen achieved sustained insulin independence (median survival, >140 days) without evidence of porcine endogenous retrovirus dissemination. Thus, neonatal porcine islets represent a promising solution to the crucial supply problem in clinical islet transplantation.

References

May 1, 1996·The Journal of Clinical Investigation·G S KorbuttR V Rajotte
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew B AdamsChristian P Larsen

❮ Previous
Next ❯

Citations

Mar 5, 2009·JAMA : the Journal of the American Medical Association·Richard N Pierson
Aug 27, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Emilio Margolles-ClarkPeter Buchwald
Sep 14, 2013·Histochemistry and Cell Biology·Markus SchweigerWerner M Amselgruber
Dec 27, 2008·Journal of Hepato-biliary-pancreatic Surgery·Hirohito Ichii, Camillo Ricordi
Aug 2, 2011·Current Diabetes Reports·Marco MariglianoRita Bottino
Aug 8, 2013·Current Diabetes Reports·Philip J O'ConnellAndrew M Lew
Oct 6, 2007·Immunologic Research·Yair Reisner
May 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gil HechtYair Reisner
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·K J PotterC B Verchere
Oct 14, 2006·Transplantation·Juliet A EmamaulleeJohn F Elliott
Jan 21, 2012·Current Opinion in Organ Transplantation·Kazuhiko Yamada, Joseph Scalea
Jan 21, 2012·Current Opinion in Organ Transplantation·Hui Wang, Yong-Guang Yang
Dec 6, 2007·Genome Biology·Karl J ClarkScott C Fahrenkrug
Feb 23, 2012·Endocrinology·Chengyang LiuMichael R Rickels
Jan 12, 2010·The Journal of Clinical Endocrinology and Metabolism·Philippe A HalbanGordon C Weir
Jun 14, 2006·PLoS Medicine·Smadar Eventov-FriedmanYair Reisner
Mar 29, 2007·PLoS Medicine·Muhammad M Mohiuddin
Dec 15, 2010·Drug Design, Development and Therapy·Gaurav Gupta, Karl L Womer
Aug 15, 2012·F1000 Medicine Reports·Adrianne L WongJulia L Greenstein
Jan 17, 2013·World Journal of Gastroenterology : WJG·Denis Dufrane, Pierre Gianello
May 13, 2014·Immunotherapy·Jun-Seop ShinChung-Gyu Park
Nov 13, 2014·Journal of Diabetes Research·Haitao ZhuBo Wang
Apr 25, 2009·Der Internist·E Jaeckel, F Lehner
Feb 25, 2011·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Melanie L GrahamHenk-Jan Schuurman
Nov 10, 2015·Expert Review of Clinical Immunology·David Kc Cooper, Rita Bottino
Dec 18, 2007·Expert Opinion on Biological Therapy·David K C CooperDavid Ayares
Dec 10, 2008·Expert Opinion on Biological Therapy·C G Thanos, R B Elliott
May 12, 2009·Expert Opinion on Biological Therapy·Juliet EmamaulleeA M James Shapiro
Jan 28, 2016·Xenotransplantation·David K C CooperRita Bottino
Apr 18, 2008·Kidney International·B SprangersA D Billiau
Mar 1, 2016·Acta Diabetologica·Silvia PellegriniLorenzo Piemonti
Jul 3, 2010·Science China. Life Sciences·ShengDian Wang, LiePing Chen
Jul 14, 2010·Transplantation Proceedings·A-Y QiaoD-C Tang
Aug 18, 2009·Molecular and Cellular Endocrinology·Marjeta GrzechMarlon R Schneider

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
D J van der WindtM Trucco
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Kenneth CardonaChristian P Larsen
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
P ThompsonA D Kirk
© 2021 Meta ULC. All rights reserved