Long-term survival rate of pediatric patients after blood transfusion

Transfusion
France GauvinHeather Hume

Abstract

Studies in adults report posttransfusion survival rate (PTSR) at 1 to 10 years of 41 to 67 percent. There are no published studies specifically addressing PTSR in pediatric patients. The objectives of this study were to evaluate PTSR and risk factors associated with death in children receiving transfusions. A database of all patients receiving their first transfusion between 1990 and 1992 at Sainte-Justine Hospital (SJH) was used. Patients' demographic data, primary diagnosis, surgical procedures, and information on all labile components transfused were collected. Death was confirmed by the SJH database, RAMQ (universal health care provider for Québec residents), and the Quebec Commission for Access to Information (death certificate). The study population consisted of 1100 children. Median age was 16 months (range, 0-204 months). The most frequent primary diagnoses were cardiac disease (22%), prematurity (21.5%), malignant disease (11%), and hematologic disease (9.5%). Patients received a median of three transfusions (range, 1-126). PTSR was 86.9 percent at 1 year and 82.3 percent at 10 years. For nonsurvivors, median survival time was 22 days. Multivariate analysis showed that significant risk factors for death are age of less...Continue Reading

References

Jun 1, 1994·Transfusion·E C Vamvakas, H F Taswell
Mar 10, 2001·Transfusion·E TynellA Björkman
Jul 31, 2002·Transfusion·Eleftherios C Vamvakas, Rosalyn Goldstein
Jul 26, 2003·Transfusion Medicine Reviews·Eleftherios C Vamvakas
Feb 27, 2004·Vox Sanguinis·S L BowkerJ K Preiksaitis
Mar 5, 2004·Transfusion·Steven KleinmanMary Patton
Jul 1, 2004·Transfusion·Jonathan P WallisCatherine E Chapman
Nov 2, 2006·Transfusion·France GauvinHeather Hume
Mar 27, 2007·Transfusion·Naomi L C LubanHarvey J Alter

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Citations

Aug 15, 2014·Pediatric Research·Cassandra D JosephsonJohn A Widness
Dec 2, 2008·Transfusion·Christopher D HillyerDaniel R Ambruso
Dec 5, 2008·Transfusion·Eleftherios C Vamvakas
Jun 18, 2010·Transfusion·Steven KleinmanDana Devine
Jun 10, 2010·Transfusion·Philip C SpinellaUNKNOWN Pediatric Acute Lung Injury and Sepsis Investigators Network
Feb 7, 2013·Paediatric Anaesthesia·Domenico Pietrini
Apr 27, 2016·Hematology/oncology Clinics of North America·Rachel S Bercovitz, Cassandra D Josephson
Apr 23, 2016·Transfusion Medicine·S L MorleyUNKNOWN EASTR study group
Mar 13, 2016·Transfusion Medicine·S L MorleyUNKNOWN EASTR study group
Mar 28, 2013·Journal of Cardiothoracic Surgery·Filomena R B G GalasLudhmila A Hajjar
Apr 19, 2018·Transfusion Medicine·G L CrightonS J Stanworth
May 6, 2008·Transfusion·Anthony D Slonim, Naomi L C Luban

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