Long-term survival rates of gravity-assisted, adjustable differential pressure valves in infants with hydrocephalus

Journal of Neurosurgery. Pediatrics
Anna-Felicitas GebertUlrich-Wilhelm Thomale

Abstract

OBJECTIVE The use of adjustable differential pressure valves with gravity-assisted units in shunt therapy of children with hydrocephalus was reported to be feasible and promising as a way to avoid chronic overdrainage. In this single-center study, the authors' experiences in infants, who have higher rates of shunt complications, are presented. METHODS All data were collected from a cohort of infants (93 patients [37 girls and 56 boys], less than 1 year of age [mean age 4.1 ± 3.1 months]) who received their first adjustable pressure hydrocephalus shunt as either a primary or secondary implant between May 2007 and April 2012. Rates of valve and shunt failure were recorded for a total of 85 months until the end of the observation period in May 2014. RESULTS During a follow-up of 54.2 ± 15.9 months (range 26-85 months), the Kaplan-Meier rate of shunt survival was 69.2% at 1 year and 34.1% at 85 months; the Kaplan-Meier rate of valve survival was 77.8% at 1 year and 56% at 85 months. Survival rates of the shunt were significantly inferior if the patients had previous shunt surgery. During follow-up, 44 valves were exchanged in cases of infection (n = 19), occlusion (n = 14), dysfunction of the adjustment unit (n = 10), or to change ...Continue Reading

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Citations

Oct 28, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·S Al-HakimU-W Thomale
Mar 28, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Sara Al-HakimUlrich-Wilhelm Thomale
Nov 22, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ibrahim AlatasHuseyin Canaz
Mar 11, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·D HendersonS Ushewokunze
Nov 13, 2020·Expert Review of Medical Devices·Paweł GutowskiUlrich-Wilhelm Thomale
Jun 22, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Hans Christoph BockHans Christoph Ludwig
Jul 10, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Víctor J Fernández Cornejo, Samer K Elbabaa
May 8, 2018·World Neurosurgery·Charlotte d'ArcanguesUlrich-Wilhelm Thomale
Nov 9, 2021·World Neurosurgery·Anna Maria AuricchioGiuseppe Talamonti

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Methods Mentioned

BETA
lavage

Software Mentioned

GraphPad Prism

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