Abstract
Hepatosplenic T-cell non-Hodgkin's lymphoma (HSTCL) is a rare, aggressive form of NHL, with a median survival of approximately 8 months. We were able to successfully induce complete remission in a patient with alpha/beta HSTCL who was refractory to multiple prior chemotherapy regimens, using the humanized anti-CD52 monoclonal antibody alemtuzumab (Campath). Once disease was controlled, the patient was able to undergo allogeneic stem cell transplantation (SCT), which resulted in complete remission. Furthermore, upon relapse, we were able to re-induce complete clinical and molecular remission with donor lymphocyte infusions. At Day 655 (post-SCT), the patient remains in complete remission. These data suggest a potential role for alemtuzumab and allogeneic SCT in the treatment of T-cell NHL.
References
Aug 1, 1996·Leukemia & Lymphoma·M YaoC H Wang
Jul 1, 1997·The American Journal of Surgical Pathology·A FrançoisH Tilly
Mar 5, 1998·Cancer·M D KrausJ A Longtine
Apr 13, 2000·American Journal of Clinical Pathology·H WuK E Salhany
Jun 24, 2000·Leukemia·E Weidmann
Jul 15, 2000·The American Journal of Surgical Pathology·F SuarezP Gaulard
Jun 23, 2001·The American Journal of Surgical Pathology·S KumarE S Jaffe
Jul 13, 2001·American Journal of Clinical Pathology·W A KhanJ C Mattson
Citations
Mar 11, 2010·International Journal of Clinical Oncology·Yuya NagaiTakayuki Takahashi
Apr 25, 2012·International Journal of Hematology·Armin RashidiStephen I Fisher
Mar 22, 2005·Bone Marrow Transplantation·M R MansourK S Peggs
Apr 8, 2006·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Vít ProcházkaDavid Starostka
Dec 3, 2010·Journal of Crohn's & Colitis·Anne Thai, Thomas Prindiville
Jul 30, 2014·Leukemia & Lymphoma·Masahiko SumiHikaru Kobayashi
Jul 7, 2007·Leukemia & Lymphoma·Simon HeAndrew Grigg
Oct 23, 2012·Leukemia & Lymphoma·Sandra Bašić KindaIgor Aurer
Jan 29, 2014·Seminars in Hematology·Nishitha M Reddy, Andrew M Evens
Apr 24, 2007·European Journal of Internal Medicine·H J MeulenbeldG J Creemers
Jan 2, 2007·Cancer Letters·Amit W Panwalkar, James O Armitage
Mar 22, 2006·European Journal of Haematology·S MittalD J Culligan
Apr 13, 2011·British Journal of Haematology·Claire E DeardenUNKNOWN British Committee for Standards in Haematology
Aug 27, 2014·European Journal of Haematology·Marco Foppoli, Andrés J M Ferreri
Sep 1, 2015·Archives of Pathology & Laboratory Medicine·Yang Shi, Endi Wang
Jun 6, 2015·Blood Cancer Journal·A Rashidi, A F Cashen
Jul 24, 2013·Clinical Lymphoma, Myeloma & Leukemia·Koppany VisnyeiIlan Shapira
Jun 7, 2005·Bone Marrow Transplantation·G G WulfB Glass
Aug 30, 2013·The Cochrane Database of Systematic Reviews·Max SchlaakPeter Kurschat
Oct 8, 2005·Blood·Mujahid A RizviSteven T Rosen
Nov 2, 2018·Medicine·Hui PanLi Wang
Aug 7, 2020·Blood·Barbara ProAmir Behdad