Long-term survival with whole abdominopelvic irradiation in platinum-refractory persistent or recurrent ovarian cancer

Gynecologic Oncology
A J Cmelak, D S Kapp

Abstract

The purpose of this study is to retrospectively evaluate the efficacy and toxicity of whole abdominopelvic irradiation (WAI) in patients with persistent or recurrent epithelial ovarian carcinoma who failed chemotherapy. Between 1970 and 1995, 41 women with persistent or recurrent ovarian carcinoma after initial treatment with surgical debulking and chemotherapy (4 to 18 cycles; median, 8) were treated with WAI. Thirty-one patients had received platinum-based regimens, and 22 of these had failed within 6 months after completion of chemotherapy ("platinum-refractory"). Prior to WAI, 11 (27%) patients had microscopic residual disease, 21 (51%) had gross residual disease up to 1.5 cm, and 9 (22%) had residual tumors greater than 1.5 cm in maximal diameter. Median doses of 28 Gy to the abdomen and 48 Gy to the pelvis were delivered using open-field techniques and liver and kidney shielding. With follow-up of 1 month to 16.5 years (median potential follow-up, 1.4 years), the 5-year actuarial disease-specific survival was 47% in all 41 patients, and 50% in the 22 platinum-refractory patients. Both residual tumor size at WAI (P < 10(-4)) and initial stage (P = 0.003) were of prognostic value. Five-year disease-specific survival of all ...Continue Reading

Citations

Sep 14, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A DebbyJ Menczer
Feb 16, 2016·Gynecologic Oncology·Anupama ChunduryJulie K Schwarz
Nov 18, 2008·The Lancet Oncology·Ajay P SinghSurinder K Batra
Jun 21, 2005·International Journal of Radiation Oncology, Biology, Physics·O W Stephanie YapAmreen Husain
Apr 12, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Francesca De FeliceVincenzo Tombolini
May 31, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Robert RomeSam Leung
Jul 9, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Maria LeeEun Ji Nam
Jul 18, 2017·Radiation Oncology Journal·Noorie ChoiHak Jae Kim

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