PMID: 7697447Apr 15, 1995Paper

Long-term survivors with HIV-1 infection: incubation period and longitudinal patterns of CD4+ lymphocytes

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
A MuñozJ P Phair

Abstract

To characterize long-term survival with HIV-1, we need to estimate the proportion of seroconverters remaining free from clinical AIDS for long periods. We predict that approximately 13% of homosexual/bisexual men infected at a young age may remain so for > 20 years. Since studies have not followed individuals for such periods, long-term survivors must be characterized using stability of immunologic markers. In a cohort of 1,809 seropositive men followed since 1984-85, 15% (187/1,214) of those with at least two consecutive visits early in the study showed no decline in CD4+ cell count. From these, 67 men with long follow-up and no use of zidovudine were identified as cases to investigate correlates of protection against HIV-1-induced immunodepletion. Two matched control subgroups, one with moderate and one with rapid CD4+ lymphocyte decline, produced 56 triplets of individuals to be contrasted. Analysis of data from early in the study on demographics, sexual behavior, and sexually transmitted diseases revealed no significant differences among the three groups. Men showing no decline in CD4+ lymphocytes persistently showed a healthier profile with respect to onset of clinical AIDS, survival, and concomitant hematologic variables....Continue Reading

Associated Clinical Trials

Citations

Dec 15, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·H FarzadeganJ B Margolick
Mar 1, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·A PetrucciG Angarano
Feb 14, 1998·AIDS Research and Human Retroviruses·Lesley J AshtonJohn M Kaldor
Mar 27, 2004·Transfusion·Jean-Jacques Lefrère, Laurence Morand-Joubert
Aug 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Liying MaPhillipe Nyambi
Mar 24, 2012·AIDS·Adrian B McDermott, Richard A Koup
Jan 1, 1997·Rehabilitation Nursing : the Official Journal of the Association of Rehabilitation Nurses·I D MontoyaW A Goodpastor
Jan 1, 1996·Lifetime Data Analysis·M ShiA Muñoz
Sep 18, 2001·AIDS Research and Human Retroviruses·S J GangeJ B Margolick
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Jun 22, 2000·The Journal of General Virology·L HoltermanJonathan L Heeney
Jan 1, 1997·Springer Seminars in Immunopathology·D V Havlir, D D Richman
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Nov 1, 2002·AIDS·Vanessa M HayesEstrelita Janse van Rensburg
Dec 1, 1996·Clinics in Chest Medicine·B Polsky

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