Long-term symptomatic control of Zenker diverticulum by flexible endoscopic mucomyotomy with the hook knife and predisposing factors for clinical recurrence

Scandinavian Journal of Gastroenterology
Juliane BruecknerStefan Karl Gölder

Abstract

Flexible endoscopic treatment for Zenker diverticulum (ZD) is well established. Although recurrence of symptoms is relatively frequent, it has hardly been studied. In the present study, we analyse the long-term development of ZD patients' symptoms after successful endoscopic mucomyotomy, as well as interventional safety, sustainability of success, and predisposing factors for clinical recurrence. Forty-six consecutive patients (54% male, mean age 67 years) with symptomatic ZD were treated using a hook knife and soft diverticuloscope. Follow-up interviews at 1 and 6 months inquired about a broad pool of symptoms and the dysphagia score. For further analysis, patients were retrospectively stratified into a 'recurrence' and 'no recurrence' group. After 100% initial success, 30% of patients reported recurrence of symptoms after 4.4 months (range 1-40) and were re-treated (mean 1.39 sessions/patient). Though the 'recurrence' group showed a higher dysphagia score and frequency past intervention, endoscopic re-treatment achieved equally good results as in the 'no recurrence' group. Before treatment, 'recurrence' patients had more severe symptoms, such as vomiting (frequency score 2.13 vs. 0.92; p < 0.05), ZD-related insomnia (1.65 vs....Continue Reading

References

Mar 1, 1992·Journal of Clinical Gastroenterology·M Dakkak, J R Bennett
Aug 1, 1995·Endoscopy·S IshiokaJ M Melo
Jun 7, 2007·World Journal of Gastroenterology : WJG·Luigi BonavinaEmmanuele Abate
Oct 2, 2007·Zentralblatt für Chirurgie·R A LangT P Hüttl
Aug 3, 2010·Mayo Clinic Proceedings·David J Case, Todd H Baron
Dec 15, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A RepiciR Rosati
Aug 30, 2011·Gastrointestinal Endoscopy·Fábio Yuji HondoPaulo Sakai
Aug 30, 2012·Expert Review of Gastroenterology & Hepatology·Ivana DzeletovicTodd H Baron
Feb 12, 2013·Gastrointestinal Endoscopy·Vincent HubertyJacques Devière
Jul 16, 2013·Gastrointestinal Endoscopy·Mohan Ramchandani, D Nageshwar Reddy
Jul 4, 2015·Scandinavian Journal of Gastroenterology·Siegbert FaissRobert Baumbach

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Citations

May 18, 2016·Gastroenterología y hepatología·Bruno A Moreira da SilvaFrancisco Igea Arisqueta
May 25, 2016·Scandinavian Journal of Gastroenterology·S K GoelderH Messmann
Dec 29, 2017·Journal of Clinical Gastroenterology·Deepanshu JainShashideep Singhal
Feb 18, 2017·Praxis·Silvan ZanderPiero V. Valli
Apr 24, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Brianna CrawleyPhilip Weissbrod
May 24, 2017·World Journal of Gastroenterology : WJG·Johanna WilmsenSiegbert Faiss
Jan 6, 2017·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·H FeußnerM Bajbouj
Mar 5, 2019·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Vicente Pons-BeltránLidia Argüello
May 18, 2021·Gastroenterology Research and Practice·Johannes ManzenederStefan Karl Goelder

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